Cell-size dependent progression of the cell cycle creates homeostasis and flexibility of plant cell size

Jones, Angharad R. ORCID: https://orcid.org/0000-0001-7493-9625, Forero-Vargas, Manuel, Withers, Simon P., Smith, Richard S., Traas, Jan, Dewitte, Walter ORCID: https://orcid.org/0000-0002-0606-1686 and Murray, James A. H. ORCID: https://orcid.org/0000-0002-2282-3839 2017. Cell-size dependent progression of the cell cycle creates homeostasis and flexibility of plant cell size. Nature Communications 8 , 15060. 10.1038/ncomms15060

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Abstract

Mean cell size at division is generally constant for specific conditions and cell types, but the mechanisms coupling cell growth and cell cycle control with cell size regulation are poorly understood in intact tissues. Here we show that the continuously dividing fields of cells within the shoot apical meristem of Arabidopsis show dynamic regulation of mean cell size dependent on developmental stage, genotype and environmental signals. We show cell size at division and cell cycle length is effectively predicted using a two-stage cell cycle model linking cell growth and two sequential cyclin dependent kinase (CDK) activities, and experimental results concur in showing that progression through both G1/S and G2/M is size dependent. This work shows that cell-autonomous co-ordination of cell growth and cell division previously observed in unicellular organisms also exists in intact plant tissues, and that cell size may be an emergent rather than directly determined property of cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	This work is licensed under a Creative Commons Attribution 4.0 International License.
Publisher:	Nature Research
ISSN:	2041-1723
Funders:	BBSRC
Date of First Compliant Deposit:	23 February 2017
Date of Acceptance:	23 February 2017
Last Modified:	19 Nov 2023 15:59
URI:	https://orca.cardiff.ac.uk/id/eprint/98516

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