Review: the role of vitamin D in nervous system health and disease

DeLuca, G. C., Kimball, S. M., Kolasinski, James ORCID: https://orcid.org/0000-0002-1599-6440, Ramagopalan, S. V. and Ebers, G. C. 2013. Review: the role of vitamin D in nervous system health and disease. Neuropathology and Applied Neurobiology 39 (5) , pp. 458-484. 10.1111/nan.12020

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Abstract

Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurological diseases. The conflation of in vitro, ex vivo, and animal model data provide compelling evidence that vitamin D has a crucial role in proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. Vitamin D exerts its biological function not only by influencing cellular processes directly, but also by influencing gene expression through vitamin D response elements. This review highlights the epidemiological, neuropathological, experimental and molecular genetic evidence implicating vitamin D as a candidate in influencing susceptibility to a number of psychiatric and neurological diseases. The strength of evidence varies for schizophrenia, autism, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, and is especially strong for multiple sclerosis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords:	amyotrophic lateral sclerosis; autism; multiple sclerosis; Parkinson's disease; schizophrenia; vitamin D
Publisher:	Wiley Blackwell
ISSN:	0305-1846
Date of Acceptance:	21 January 2013
Last Modified:	21 Oct 2022 06:57
URI:	https://orca.cardiff.ac.uk/id/eprint/98838

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