From physiology, genomes, systems, and self-organization to systems biology: the historical roots of a twenty-first century approach to complexity

Aon, M. A., Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 and Saks, V. 2014. From physiology, genomes, systems, and self-organization to systems biology: the historical roots of a twenty-first century approach to complexity. Aon, Miguel A., Saks, Valdur and Schlattner, Uwe, eds. Systems Biology of Metabolic and Signaling Networks: Energy, Mass and Information Transfer, Vol. 16. Springer Series in Biophysics, Springer, pp. 3-17. (10.1007/978-3-642-38505-6_1)

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Abstract

Systems Biology represents a new paradigm aiming at a whole organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. Historically, the roots of Systems Biology are multiple and of a diverse nature, comprising theoretical and conceptual developments, mathematical and modeling tools, and comprehensive analytical methodologies aimed at listing molecular components. As a systemic approach, modern Systems Biology is deeply rooted in Integrative Physiology from which it inherits two big foundational principles: (1) a non-reductionist, integrative, view and (2) the capability of defining the context within which genes and their mutations will find meaning.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Subjects:	Q Science > Q Science (General)
Publisher:	Springer
ISBN:	9783642385049
ISSN:	09322353
Last Modified:	21 Oct 2022 06:59
URI:	https://orca.cardiff.ac.uk/id/eprint/98924

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