Howard, Jennifer, Loizon, Séverine, Tyler, Christopher J., Duluc, Dorothée, Moser, Bernhard  ORCID: https://orcid.org/0000-0002-4354-4572, Mechain, Matthieu, Duvignaud, Alexandre, Malvy, Denis, Troye-Blomberg, Marita, Moreau, Jean-Francois, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Mercereau-Puijalon, Odile, Déchanet-Merville, Julie, Behr, Charlotte and Mamani-Matsuda, Maria
2017.
The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.
Journal of Infectious Diseases
215
(10)
, pp. 1569-1579.
10.1093/infdis/jix149
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Abstract
During Plasmodium falciparum infections, erythrocyte-stage parasites inhibit dendritic cell maturation and function; compromising development of effective anti-malarial adaptive immunity. Human Vγ9Vδ2 T-cells can act in vitro as APCs and induce αβ T-cell activation. However, the relevance of this activity in pathophysiological contexts in vivo has remained elusive. Since Vγ9Vδ2 T-cells are activated during the early immune response against P.falciparum infection, we investigated whether they could contribute to the instruction of adaptive immune responses toward malaria parasites. In P.falciparum-infected patients,Vγ9Vδ2 T-cells presented an increased surface expression of APC-associated markers HLA-DR and CD86. In response to infected red blood cells in vitro, Vγ9Vδ2 T-cells readily up-regulated surface expression of HLA-DR, HLA-ABC, CD40, CD80, CD83 and CD86, induced naive αβ T-cell responses, and cross-presented soluble prototypical protein to antigen-specific CD8+ T-cells. Our findings indicate that P. falciparum parasites induce genuine APC properties in Vγ9Vδ2 T-cells and qualify this subset as an alternative professional APC in malaria patients, which could be harnessed for therapeutic interventions and vaccine design.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Oxford University Press |
| ISSN: | 0022-1899 |
| Date of First Compliant Deposit: | 30 March 2017 |
| Date of Acceptance: | 17 March 2017 |
| Last Modified: | 04 Dec 2024 01:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/99539 |
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