Browse by Current Cardiff authors

Beaufort, Nathalie, Scharrer, Eva, Kremmer, Elisabeth, Lux, Vanda, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Huber, Robert, Houlden, Henry, Werring, David, Haffner, Christof and Dichgans, Martin 2014. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America 111 (46) , 16496. 10.1073/pnas.1418087111

Lesca, E., Lammens, A., Huber, Robert and Augustin, M. 2014. Structural analysis of the human fibroblast growth factor receptor 4 kinase. Journal of Molecular Biology 426 (22) , pp. 3744-3756. 10.1016/j.jmb.2014.09.004

Arciniega, Marcelino, Beck, Phillipp, Lange, Oliver F., Groll, Michael and Huber, Robert 2014. Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding. Proceedings of the National Academy of Sciences of the United States of America 111 (26) , pp. 9479-9484. 10.1073/pnas.1408018111

Kiefersauer, Reiner, Grandl, Brigitte, Krapp, Stephan and Huber, Robert 2014. IR laser-induced protein crystal transformation. Acta Crystallographica Section D Biological Crystallography 70 (5) , pp. 1224-1232. 10.1107/S1399004714002223

Huber, Robert 2013. "How I chose research on proteases or, more correctly, how it chose me". Angewandte Chemie - International Edition 52 (1) , pp. 68-73. 10.1002/anie.201205629

Baek, Sohee, Kang, Nam Joo, Popowicz, Grzegorz M., Arciniega, Marcelino, Jung, Sung Keun, Byun, Sanguine, Song, Nu Ry, Heo, Yong-Seok, Kim, Bo Yeon, Lee, Hyong Joo, Holak, Tad A., Augustin, Martin, Bode, Ann M., Huber, Robert, Dong, Zigang and Lee, Ki Won 2013. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. Journal of Molecular Biology 425 (2) , pp. 411-423. 10.1016/j.jmb.2012.10.019

Huber, Robert 2013. Recortar en ciencia es amputar el futuro. SEBBM: Sociedad Española de Bioquímica y Biología Molecular 175 , pp. 23-25.

Schneider, E. V., Bottcher, J., Huber, Robert, Maskos, K. and Neumann, L. 2013. Structure-kinetic relationship study of CDK8/CycC specific compounds. Proceedings of the National Academy of Sciences of the United States of America 110 (20) , pp. 8081-8086. 10.1073/pnas.1305378110

Weski, Juliane, Meltzer, Michael, Spaan, Lina, Mönig, Timon, Oeljeklaus, Julian, Hauske, Patrick, Vouilleme, Lars, Volkmer, Rudolf, Boisguerin, Prisca, Boyd, Dana, Huber, Robert, Kaiser, Markus and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2012. Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease. Chembiochem 13 (3) , pp. 402-408. 10.1002/cbic.201100643

Tennstaedt, A., Popsel, S., Truebestein, L., Hauske, P., Brockmann, A., Schmidt, N., Irle, I., Sacca, B., Niemeyer, C. M., Brandt, R., Ksiezak-Reding, H., Tirniceriu, A. L., Egensperger, R., Baldi, A., Dehmelt, L., Kaiser, M., Huber, Robert, Clausen, T. and Ehrmann, M. 2012. Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates. Journal of Biological Chemistry 287 (25) , pp. 20931-20941. 10.1074/jbc.M111.316232

Baek, Sohee, Kutchukian, Peter S., Verdine, Gregory L., Huber, Robert, Holak, Tad A., Lee, Ki Won and Popowicz, Grzegorz M. 2012. Structure of the Stapled p53 Peptide Bound to Mdm2. Journal of the American Chemical Society 134 (1) , pp. 103-106. 10.1021/ja2090367

Gallastegui, Nerea, Beck, Philipp, Arciniega, Marcelino, Huber, Robert, Hillebrand, Stefan and Groll, Michael 2012. Hydroxyureas as Noncovalent Proteasome Inhibitors. Angewandte Chemie - International Edition 51 (1) , pp. 247-249. 10.1002/anie.201106010

Merdanovic, Melisa, Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2011. Protein quality control in the bacterial periplasm. Annual Review of Microbiology 65 (1) , pp. 149-168. 10.1146/annurev-micro-090110-102925

Schneider, E. V., Böttcher, J., Blaesse, M., Neumann, L., Huber, Robert and Maskos, K. 2011. The structure of CDK8/CycC implicates specificity in the CDK/Cyclin family and reveals interaction with a deep pocket binder. Journal of Molecular Biology 412 (2) , pp. 251-266. 10.1016/j.jmb.2011.07.020

Gräwert, Melissa Ann, Gallastegui, Nerea, Stein, Martin, Schmidt, Boris, Kloetzel, Peter-Michael, Huber, Robert and Groll, Michael 2011. Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition. Angewandte Chemie - International Edition 50 (2) , pp. 542-544. 10.1002/anie.201005488

Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2011. HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3) , pp. 152-162. 10.1038/nrm3065

Sitar, T., Gallinger, J., Ducka, A. M., Ikonen, T. P., Wohlhoefler, M., Schmoller, K. M., Bausch, A. R., Joel, P., Trybus, K. M., Noegel, A. A., Schleicher, M., Huber, Robert and Holak, T. A. 2011. Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly. Proceedings of the National Academy of Sciences 108 (49) , pp. 19575-19580. 10.1073/pnas.1115465108

Clerc, Jérôme, Schellenberg, Barbara, Groll, Michael, Bachmann, André S., Huber, Robert, Dudler, Robert and Kaiser, Markus 2010. Convergent synthesis and biological evaluation of syringolin A and derivatives as eukaryotic 20S proteasome inhibitors. European Journal of Organic Chemistry 2010 (21) , pp. 3991-4003. 10.1002/ejoc.201000317

Merdanovic, Melisa, Mamant, Nicolette, Meltzer, Michael, Poepsel, Simon, Auckenthaler, Alexandra, Melgaard, Rie, Hauske, Patrick, Nagel-Steger, Luitgard, Clarke, Anthony R, Kaiser, Markus, Huber, Robert and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nature Structural & Molecular Biology 17 (7) , pp. 837-843. 10.1038/nsmb.1839

Krojer, Tobias, Sawa, Justyna, Huber, Robert and Clausen, Tim 2010. HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nature Structural & Molecular Biology 17 (7) , pp. 844-852. 10.1038/nsmb.1840

Ducka, A. M., Joel, P., Popowicz, G. M., Trybus, K. M., Schleicher, M., Noegel, A. A., Huber, Robert, Holak, T. A. and Sitar, T. 2010. Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proceedings of the National Academy of Sciences 107 (26) , pp. 11757-11762. 10.1073/pnas.1005347107

Hasenbein, Sonja, Meltzer, Michael, Hauske, Patrick, Kaiser, Markus, Huber, Robert, Clausen, Tim and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2010. Conversion of a regulatory into a degradative protease. Journal of Molecular Biology 397 (4) , pp. 957-966. 10.1016/j.jmb.2010.02.027

Groll, Michael, Gallastegui, Nerea, Maréchal, Xavier, Le Ravalec, Virginie, Basse, Nicolas, Richy, Nicolas, Genin, Emilie, Huber, Robert, Moroder, Luis, Vidal, Joëlle and Reboud-Ravaux, Michèle 2010. 20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A. ChemMedChem 5 (10) , pp. 1701-1705. 10.1002/cmdc.201000293

Merdanovic, Melisa, Mamant, Nicolette, Meltzer, Michael, Poepsel, Simon, Auckenthaler, Alexandra, Melgaard, Rie, Hauske, Patrick, Nagel-Steger, Luitgard, Clarke, Anthony, Kaiser, Markus, Huber, Robert and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nature Structural & Molecular Biology 17 (7) , pp. 837-843. 10.1038/nsmb.1839

Clerc, Jérôme, Florea, Bogdan I., Kraus, Marianne, Groll, Michael, Huber, Robert, Bachmann, André S., Dudler, Robert, Driessen, Christoph, Overkleeft, Herman S. and Kaiser, Markus 2009. Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines. ChemBioChem 10 (16) , pp. 2638-2643. 10.1002/cbic.200900411

Meltzer, Michael, Hasenbein, Sonja, Mamant, Nicolette, Merdanovic, Melisa, Poepsel, Simon, Hauske, Patrick, Kaiser, Markus, Huber, Robert, Krojer, Tobias, Clausen, Tim and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2009. Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology 160 (9) , pp. 660-666. 10.1016/j.resmic.2009.07.012

Breithaupt, Constanze, Kurzbauer, Robert, Schaller, Florian, Stintzi, Annick, Schaller, Andreas, Huber, Robert, Macheroux, Peter and Clausen, Tim 2009. Structural basis of substrate specificity of plant 12-oxophytodienoate reductases. Journal of Molecular Biology 392 (5) , pp. 1266-1277. 10.1016/j.jmb.2009.07.087

Ottmann, C., Rose, R., Huttenlocher, F., Cedzich, A., Hauske, P., Kaiser, M., Huber, Robert and Schaller, A. 2009. Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3. Proceedings of the National Academy of Sciences 106 (40) , pp. 17223-17228. 10.1073/pnas.0907587106

Lee, Jung- Hoo, Maskos, Klaus and Huber, Robert 2009. Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. Journal of Molecular Biology 391 (4) , pp. 744-757. 10.1016/j.jmb.2009.06.059

Wolschner, C., Giese, A., Kretzschmar, H., Huber, Robert, Moroder, L. and Budisa, N. 2009. Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein. Proceedings of the National Academy of Sciences 106 (19) , pp. 7756-7761. 10.1073/pnas.0902688106

Clerc, J., Groll, M., Illich, D. J., Bachmann, A. S., Huber, Robert, Schellenberg, B., Dudler, R. and Kaiser, M. 2009. Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition. Proceedings of the National Academy of Sciences 106 (16) , pp. 6507-6512. 10.1073/pnas.0901982106

Groll, Michael, Huber, Robert and Moroder, Luis 2009. The persisting challenge of selective and specific proteasome inhibition. Journal of Peptide Science 15 (2) , pp. 58-66. 10.1002/psc.1107

Sanglas, L., Aviles, F., Huber, Robert, Gomis-Ruth, F. and Arolas, J. 2009. Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. Proceedings of the National Academy of Sciences 106 (6) , pp. 1743-1747. 10.1073/pnas.0812623106

Krojer, Tobias, Pangerl, Karen, Kurt, Juliane, Sawa, Justyne, Stingl, Christoph, Mechtler, Karl, Huber, Robert, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Clausen, Tim 2008. Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proceedings of the National Academy of Sciences 105 (22) , pp. 7702-7707. 10.1073/pnas.0803392105

Breithaupt, C, Schäfer, B, Pellkofer, H, Huber, Robert, Linington, C and Jacob, U 2008. Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents. Journal of Immunology 181 (2) , pp. 1255-63.

Krojer, T., Pangerl, K., Kurt, J., Sawa, J., Stingl, C., Mechtler, K., Huber, Robert, Ehrmann, M. and Clausen, T. 2008. Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proceedings of the National Academy of Sciences of the United States of America 105 (22) , pp. 7702-7. 10.1073/pnas.0803392105

Groll, M., Schellenberg, B., Bachmann, A. S., Archer, C. R., Huber, Robert, Powell, T. K., Lindow, S., Kaiser, M. and Dudler, R. 2008. A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature 452 (7188) , pp. 755-758. 10.1038/nature06782

Borelli, C., Ruge, E., Lee, J. H., Schaller, M., Vogelsang, A., Monod, M., Korting, H. C., Huber, Robert and Maskos, K. 2008. X-ray structures of Sap 1 and Sap5: Structural comparison of the secreted aspartic proteinases from Candida albicans. Proteins: Structure, Function and Bioinformatics 72 (4) , pp. 1308-1319. 10.1002/prot.22021

Chatwell, L., Illarionova, V., Illarionov, B., Eisenreich, W., Huber, Robert, Skerra, A., Bacher, A. and Fischer, M. 2008. Structure of lumazine protein, an optical transponder of luminescent bacteria. Journal for Molecular Biology 382 (1) , pp. 44-55. 10.1016/j.jmb.2008.06.052

Debela, Mekdes, Goettig, Peter, Magdolen, Viktor, Huber, Robert, Schechter, Norman M. and Bode, Wolfram 2007. Structural basis of the zinc inhibition of human tissue kallikrein 5. Journal of Molecular Biology 373 (4) , pp. 1017-1031. 10.1016/j.jmb.2007.08.042

Debela, M., Hess, P., Magdolen, V., Schechter, N. M., Steiner, T., Huber, Robert, Bode, W. and Goettig, P. 2007. Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7. Proceedings of the National Academy of Sciences of the United States of America 104 (41) , pp. 16086-16091. 10.1073/pnas.0707811104

Velarde, Milko, Huber, Robert, Yanagisawa, Sachiko, Dennison, Christopher and Messerschmidt, Albrecht 2007. Influence of loop shortening on the metal binding site of cupredoxin pseudoazurin. Biochemistry 46 (35) , pp. 9981-9991. 10.1021/bi701113w

Tochowicz, Anna, Maskos, Klaus, Huber, Robert, Oltenfreiter, Ruth, Dive, Vincent, Yiotakis, Athanasios, Zanda, Matteo, Bode, Wolfram and Goettig, Peter 2007. Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity. Journal of Molecular Biology 371 (4) , pp. 989-1006. 10.1016/j.jmb.2007.05.068

Borelli, Claudia, Ruge, Elisabeth, Schaller, Martin, Monod, Michel, Korting, Hans Christian, Huber, Robert and Maskos, Klaus 2007. The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A. Proteins: Structure, Function and Bioinformatics 68 (3) , pp. 738-748. 10.1002/prot.21425

Steiner, T., Lamerz, A.-C., Hess, P., Breithaupt, C., Krapp, S., Bourenkov, G., Huber, Robert, Gerardy-Schahn, R. and Jacob, U. 2007. Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major. Journal of Biological Chemistry 282 (17) , pp. 13003-13010. 10.1074/jbc.M609984200

Kyrieleis, Otto J. P., Huber, Robert, Ong, Edgar, Oehler, Ryan, Hunter, Mike, Madison, Edwin L. and Jacob, Uwe 2007. Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family. FEBS Journal 274 (8) , pp. 2148-2160. 10.1111/j.1742-4658.2007.05756.x

Keil, Cora, Maskos, Klaus, Than, Manuel, Hoopes, J. Todd, Huber, Robert, Tan, Fulong, Deddish, Peter A., Erdös, Ervin G., Skidgel, Randal A. and Bode, Wolfram 2007. Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain. Journal of Molecular Biology 366 (2) , pp. 504-516. 10.1016/j.jmb.2006.11.025

Huber, Robert, de Meijere, A., Groll, M. and Larionov, O.V. 2006. Inhibitor-binding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation. Proceedings of National Academy of Sciences USA , pp. 4576-4579. 10.1073/pnas.0600647103

Debela, Mekdes, Magdolen, Viktor, Grimminger, Valerie, Sommerhoff, Christian, Messerschmidt, Albrecht, Huber, Robert, Friedrich, Rainer, Bode, Wolfram and Goettig, Peter 2006. Crystal structures of human tissue kallikrein 4: Activity modulation by a specific zinc binding site. Journal of Molecular Biology 362 (5) , pp. 1094-1107. 10.1016/j.jmb.2006.08.003

Breithaupt, C., Kurzbauer, R., Lilie, H., Schaller, A., Strassner, J., Huber, Robert, Macheroux, P. and Clausen, T. 2006. Crystal structure of 12-oxophytodienoate reductase 3 from tomato: Self-inhibition by dimerization. Proceedings of the National Academy of Sciences of the United States of America 103 (39) , pp. 14337-13342. 10.1073/pnas.0606603103

Tamulaitiene, Giedre, Jakubauskas, Arturas, Urbanke, Claus, Huber, Robert, Grazulis, Saulius and Siksnys, Virginijus 2006. The crystal structure of the rare-cutting restriction enzyme SdaI reveals unexpected domain architecture. Structure 14 (9) , pp. 1389-1400. 10.1016/j.str.2006.07.002

Sitar, T., Popowicz, G. M., Siwanowicz, I., Huber, Robert and Holak, T. A. 2006. Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 103 (35) , pp. 13028-13033. 10.1073/pnas.0605652103

Chatwell, Lorenz, Krojer, Tobias, Fidler, Alexander, Römisch, Werner, Eisenreich, Wolfgang, Bacher, Adelbert, Huber, Robert and Fischer, Markus 2006. Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5′-phosphate reductase of methanocaldococcus jannaschii. Journal of Molecular Biology 359 (5) , pp. 1334-1351. 10.1016/j.jmb.2006.04.045

Groll, Michael, Huber, Robert and Potts, Barbara C. M. 2006. Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of β-lactone ring opening and a mechanism for irreversible binding. Journal of the American Chemical Society 128 (15) , pp. 5136-5141. 10.1021/ja058320b

Engel, Michael, Hoffmann, Torsten, Manhart, Susanne, Heiser, Ulrich, Chambre, Sylvie, Huber, Robert, Demuth, Hans-Ulrich and Bode, Wolfram 2006. Rigidity and flexibility of Dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV. Journal of Molecular Biology 355 (4) , pp. 768-783. 10.1016/j.jmb.2005.11.014

Arolas, Joan L., Popowicz, Grzegorz M., Bronsoms, Sílvia, Aviles, Francesc X., Huber, Robert, Holak, Tad A. and Ventura, Salvador 2005. Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond. Journal of Molecular Biology 352 (4) , pp. 961-975. 10.1016/j.jmb.2005.07.065

Groll, Michael, Bochtler, Matthias, Brandstetter, Hans, Clausen, Tim and Huber, Robert 2005. Molecular machines for protein degradation. ChemBioChem 6 (2) , pp. 222-256. 10.1002/cbic.200400313

Siwanowicz, Igor, Popowicz, Grzegorz M., Wisniewska, Magdalena, Huber, Robert, Kuenkele, Klaus-Peter, Lang, Kurt, Engh, Richard A. and Holak, Tad A. 2005. Structural basis for the regulation of insulin-like growth factors by IGF binding proteins. Structure 13 (1) , pp. 155-167. 10.1016/j.str.2004.11.009

Ramsperger, A., Augustin, M., Schott, A.-K., Gerhardt, S., Krojer, T., Eisenreich, W., Illarionov, B., Cushman, M., Bacher, A., Huber, Robert and Fischer, M. 2005. Crystal structure of an archaeal pentameric Rriboflavin synthase in complex with a substrate analog inhibitor: STEREOCHEMICAL IMPLICATIONS. Journal of Biological Chemistry 281 (2) , pp. 1224-1232. 10.1074/jbc.M509440200

Golbik, Ralph, Yu, Chao, Weyher-Stingl, Elisabeth, Huber, Robert, Moroder, Luis, Budisa, Nediljko and Schiene-Fischer, Cordelia 2005. Peptidyl prolylcis/trans-isomerases: Comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates. Biochemistry 44 (49) , pp. 16026-16034. 10.1021/bi051442w

Einsle, Oliver, Niessen, Holger, Abt, Dietmar J., Seiffert, Grazyna, Schink, Bernhard, Huber, Robert, Messerschmidt, Albrecht and Kroneck, Peter M. H. 2005. Crystallization and preliminary X-ray analysis of the tungsten-dependent acetylene hydratase fromPelobacter acetylenicus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61 (3) , pp. 299-301. 10.1107/S174430910500374X

Groll, Michael and Huber, Robert 2005. Purification, crystallization, and X-ray analysis of the yeast 20S proteasome. Methods in Enzymology 398 , pp. 329-336. 10.1016/S0076-6879(05)98027-0

Grazulis, S., Manakova, E., Roessle, M., Bochtler, M., Tamulaitiene, G., Huber, Robert and Siksnys, V. 2005. Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proceedings of the National Academy of Sciences of the United States of America 102 (44) , pp. 15797-15802. 10.1073/pnas.0507949102

Breitenlechner, Christine B., Kairies, Norman A., Honold, Konrad, Scheiblich, Stefan, Koll, Hans, Greiter, Eva, Koch, Stefan, Schäfer, Wolfgang, Huber, Robert and Engh, Richard A. 2005. Crystal structures of active Src kinase domain complexes. Journal of Molecular Biology 353 (2) , pp. 222-231. 10.1016/j.jmb.2005.08.023

Goettig, P., Brandstetter, H., Groll, M., Gohring, W., Konarev, P. V., Svergun, D. I., Huber, Robert and Kim, J.-S. 2005. X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from thermoplasma acidophilum. Journal of Biological Chemistry 280 (39) , pp. 33387-33396. 10.1074/jbc.M505030200

Arolas, Joan L., Popowicz, Grzegorz M., Lorenzo, Julia, Sommerhoff, Christian P., Huber, Robert, Aviles, Francesc X. and Holak, Tad A. 2005. The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode. Journal of Molecular Biology 350 (3) , pp. 489-498. 10.1016/j.jmb.2005.05.015

Kyrieleis, Otto J.P., Goettig, Peter, Kiefersauer, Reiner, Huber, Robert and Brandstetter, Hans 2005. Crystal structures of the tricorn interacting factor F3 from thermoplasma acidophilum, a zinc aminopeptidase in three different conformations. Journal of Molecular Biology 349 (4) , pp. 787-800. 10.1016/j.jmb.2005.03.070

Than, Manuel E., Henrich, Stefan, Bourenkov, Gleb P., Bartunik, Hans D., Huber, Robert and Bode, Wolfram 2005. The endoproteinase furin contains two essential Ca2+ions stabilizing its N-terminus and the unique S1 specificity pocket. Acta Crystallographica Section D: Biological Crystallography 61 (5) , pp. 505-512. 10.1107/S0907444905002556

Wisniewska, Magdalena, Bossenmaier, Birgit, Georges, Guy, Hesse, Friederike, Dangl, Markus, Künkele, Klaus-Peter, Ioannidis, Ioannis, Huber, Robert and Engh, Richard A. 2005. The 1.1Å resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. Journal of Molecular Biology 347 (5) , pp. 1005-1014. 10.1016/j.jmb.2005.02.017

Pal, Prajna P., Bae, Jae Hyun, Azim, M. Kamran, Hess, Petra, Friedrich, Rainer, Huber, Robert, Moroder, Luis and Budisa, Nediljko 2005. Structural and spectral response of Aequorea victoria green fluorescent proteins to chromophore fluorination? Biochemistry 44 (10) , pp. 3663-3672. 10.1021/bi0484825

Huber, Robert, Theodoratou, E. and Böck, A. 2005. [NiFe]-Hydrogenase maturation endopeptidase: structure and function. Biochemical Society Transactions 33 (1) , pp. 108-111. 10.1042/BST0330108

Jauch, R., Humm, A., Huber, Robert and Wahl, M. C. 2005. Structures of Escherichia coli NAD Synthetase with substrates and products reveal mechanistic rearrangements. Journal of Biological Chemistry 280 (15) , pp. 15131-15140. 10.1074/jbc.M413195200

Kaiser, Markus, Groll, Michael, Siciliano, Carlo, Assfalg-Machleidt, Irmgard, Weyher, Elisabeth, Kohno, Jun, Milbradt, Alexander G., Renner, Christian, Huber, Robert and Moroder, Luis 2004. Binding mode of TMC-95A analogues to eukaryotic 20S proteasome. Chembiochem 5 (9) , pp. 1256-1266. 10.1002/cbic.200400096

Echt, Stefanie, Bauer, Stefanie, Steinbacher, Stefan, Huber, Robert, Bacher, Adelbert and Fischer, Markus 2004. Potential Anti-infective Targets in Pathogenic Yeasts: Structure and Properties of 3,4-Dihydroxy-2-butanone 4-phosphate Synthase of Candida albicans. Journal of Molecular Biology 341 (4) , pp. 1085-1096. 10.1016/j.jmb.2004.06.053

Wenig, K., Chatwell, L., von Pawel-Rammingen, U., Bjorck, L., Huber, Robert and Sondermann, P. 2004. Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. Proceedings of the National Academy of Sciences of the United States of America 101 (50) , pp. 17371-17376. 10.1073/pnas.0407965101

Groll, Michael and Huber, Robert 2004. Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1695 (1-3) , pp. 33-44. 10.1016/j.bbamcr.2004.09.025

Stanitzek, Susanne, Augustin, Martin A., Huber, Robert, Kupke, Thomas and Steinbacher, Stefan 2004. Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by escherichia coli PPC synthetase. Structure 12 (11) , pp. 1977-1988. 10.1016/j.str.2004.08.007

Fischer, Markus, Schott, Anne-Kathrin, Römisch, Werner, Ramsperger, Arne, Augustin, Martin, Fidler, Alexander, Bacher, Adelbert, Richter, Gerald, Huber, Robert and Eisenreich, Wolfgang 2004. Evolution of vitamin B2 biosynthesis. a novel class of riboflavin synthase in archaea. Journal of Molecular Biology 343 (1) , pp. 267-278. 10.1016/j.jmb.2004.08.016

Popowicz, Grzegorz M., Müller, Rolf, Noegel, Angelika A., Schleicher, Michael, Huber, Robert and Holak, Tad A. 2004. Molecular structure of the rod domain of Dictyostelium filamin. Journal of Molecular Biology 342 (5) , pp. 1637-1646. 10.1016/j.jmb.2004.08.017

Bonin, I., Muhlberger, R., Bourenkov, G. P., Huber, Robert, Bacher, A., Richter, G. and Wahl, M. C. 2004. Structural basis for the interaction of Escherichia coli NusA with protein N of phage λ. Proceedings of the National Academy of Sciences of the United States of America 101 (38) , pp. 13762-13767. 10.1073/pnas.0405883101

Keil, Cora, Huber, Robert, Bode, Wolfram and Than, Manuel E. 2004. Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP. Acta Crystallographica Section D: Biological Crystallography 60 (9) , pp. 1614-1617. 10.1107/S0907444904015343

Koch, Michael, Breithaupt, Constanze, Gerhardt Haase, Stefan Ilka, Weber, Stefan, Cushman, Mark, Huber, Robert, Bacher, Adelbert and Fischer, Markus 2004. Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase. European Journal of Biochemistry 271 (15) , pp. 3208-3214. 10.1111/j.1432-1033.2004.04253.x

Bonin, Irena, Martins, Berta M., Purvanov, Vladimir, Fetzner, Susanne, Huber, Robert and Dobbek, Holger 2004. Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase. Structure 12 (8) , pp. 1425-1435. 10.1016/j.str.2004.05.014

Laupitz, Ralf, Hecht, Stefan, Amslinger, Sabine, Zepeck, Ferdinand, Kaiser, Johannes, Richter, Gerald, Schramek, Nicholas, Steinbacher, Stefan, Huber, Robert, Arigoni, Duilio, Bacher, Adelbert, Eisenreich, Wolfgang and Rohdich, Felix 2004. Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. European Journal of Biochemistry 271 (13) , pp. 2658-2669. 10.1111/j.1432-1033.2004.04194.x

Comellas-Bigler, Mireia, Maskos, Klaus, Huber, Robert, Oyama, Hiroshi, Oda, Kohei and Bode, Wolfram 2004. 1.2 Å crystal structure of the serine carboxyl proteinase pro-kumamolisin. Structure 12 (7) , pp. 1313-1323. 10.1016/j.str.2004.04.013

Breitenlechner, Christine, Engh, Richard A., Huber, Robert, Kinzel, Volker, Bossemeyer, Dirk and Gassel, Michael 2004. The typically disordered N-Terminus of PKA can fold as a helix and project the myristoylation site into solution? Biochemistry 43 (24) , pp. 7743-7749. 10.1021/bi0362525

Bauer, Stefanie, Schott, Ann-Kathrin, Illarionova, Victoria, Bacher, Adelbert, Huber, Robert and Fischer, Markus 2004. Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from arabidopsis thaliana reveals a novel adolase class. Journal of Molecular Biology 339 (4) , pp. 967-979. 10.1016/j.jmb.2004.04.034

Bader, Gerd, Gomez-Ortiz, Mariola, Haussmann, Christoph, Bacher, Adelbert, Huber, Robert and Fischer, Markus 2004. Structure of the molybdenum-cofactor biosynthesis protein MoaB ofEscherichia coli. Acta Crystallographica Section D: Biological Crystallography 60 (6) , pp. 1068-1075. 10.1107/S0907444904007164

Gassel, M., Breitenlechner, C. B., Konig, N., Huber, Robert, Engh, R. A. and Bossemeyer, D. 2004. The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. Journal of Biological Chemistry 279 (22) , pp. 23679-23690. 10.1074/jbc.M314082200

Bae, Jae Hyun, Paramita Pal, Prajna, Moroder, Luis, Huber, Robert and Budisa, Nediljko 2004. Crystallographic evidence for isomeric chromophores in 3-fluorotyrosyl-green fluorescent protein. Chembiochem 5 (5) , pp. 720-722. 10.1002/cbic.200300818

Koch, Michael, Breithaupt, Constanze, Kiefersauer, Reiner, Freigang, Jörg, Huber, Robert and Messerschmidt, Albrecht 2004. Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis. EMBO Journal 23 (8) , pp. 1720-1728. 10.1038/sj.emboj.7600189

Fritze, Iris M., Linden, Lars, Freigang, Jorg, Auerbach, Gunter, Huber, Robert and Steinbacher, Stefan 2004. The crystal structures of zea mays and arabidopsis 4-hydroxyphenylpyruvate dioxygenase. Plant Physiology 134 (4) , pp. 1388-1400. 10.1104/pp.103.034082

Breitenlechner, Christine B., Wegge, Thomas, Berillon, Laurent, Graul, Klaus, Marzenell, Klaus, Friebe, Walter-Gunar, Thomas, Ulrike, Schumacher, Ralf, Huber, Robert, Engh, Richard A. and Masjost, Birgit 2004. Structure-based optimization of novel azepane derivatives as PKB Inhibitors. Journal of Medicinal Chemistry 47 (6) , pp. 1375-1390. 10.1021/jm0310479

Than, Manuel E., Helm, Michael, Simpson, David J., Lottspeich, Friedrich, Huber, Robert and Gietl, Christine 2004. The 2.0Å crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of ricinus communis endosperm. Journal of Molecular Biology 336 (5) , pp. 1103-1116. 10.1016/j.jmb.2003.12.075

Kim, Jeong-Sun, Kluskens, Leon D., de Vos, Willem M., Huber, Robert and van der Oost, John 2004. Crystal structure of fervidolysin from fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin. Journal of Molecular Biology 335 (3) , pp. 787-797. 10.1016/j.jmb.2003.11.006

Bauer, Stefanie, Kemter, Kristina, Bacher, Adelbert, Huber, Robert, Fischer, Markus and Steinbacher, Stefan 2003. Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold. Journal of Molecular Biology 326 (5) , pp. 1463-1473. 10.1016/S0022-2836(03)00059-7

Svetlitchnyi, V., Dobbek, H., Meyer-Klaucke, W., Meins, T., Thiele, B., Romer, P., Huber, Robert and Meyer, O. 2003. A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans. Proceedings of the National Academy of Sciences of the United States of America 101 (2) , pp. 446-451. 10.1073/pnas.0304262101

Krapp, Stephan, Münster-Kühnel, Anja K., Kaiser, Jens T., Huber, Robert, Tiralongo, Joe, Gerardy-Schahn, Rita and Jacob, Uwe 2003. The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase. Journal of Molecular Biology 334 (4) , pp. 625-637. 10.1016/j.jmb.2003.09.080

Breitenlechner, Christine, Gaßel, Michael, Hidaka, Hiroyoshi, Kinzel, Volker, Huber, Robert, Engh, Richard A and Bossemeyer, Dirk 2003. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure 11 (12) , pp. 1595-1607. 10.1016/j.str.2003.11.002

Hofmann, Andreas and Huber, Robert 2003. Liposomes in assessment of annexin–membrane interactions. Methods in Enzymology 372 , pp. 186-216. 10.1016/S0076-6879(03)72011-4

Steinbacher, S., Schiffmann, S., Richter, G., Huber, Robert, Bacher, A. and Fischer, M. 2003. Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-Phosphate. Journal of Biological Chemistry 278 (43) , pp. 42256-42265. 10.1074/jbc.M307301200

Friedrich, Rainer, Panizzi, Peter, Fuentes-Prior, Pablo, Richter, Klaus, Verhamme, Ingrid, Anderson, Patricia J., Kawabata, Shun-Ichiro, Huber, Robert, Bode, Wolfram and Bock, Paul E. 2003. Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Nature 425 (6957) , pp. 535-539. 10.1038/nature01962

Almeida, Maria Gabriela, Macieira, Sofia, Goncalves, Luisa L., Huber, Robert, Cunha, Carlos A., Romao, Maria Joao, Costa, Cristina, Lampreia, Jorge, Moura, Jose J. G. and Moura, Isabel 2003. The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774. European Journal of Biochemistry 270 (19) , pp. 3904-3915. 10.1046/j.1432-1033.2003.03772.x

Macieira, Sofia, Martins, Berta M. and Huber, Robert 2003. Oxygen-dependent coproporphyrinogen-III oxidase fromEscherichia coli: one-step purification and biochemical characterisation. FEMS Microbiology Letters 226 (1) , pp. 31-37. 10.1016/S0378-1097(03)00531-7

Jozic, Daniela, Kaiser, Jens T., Huber, Robert, Bode, Wolfram and Maskos, Klaus 2003. X-ray structure of isoaspartyl dipeptidase from E.coli: A dinuclear zinc peptidase evolved from amidohydrolases. Journal of Molecular Biology 332 (1) , pp. 243-256. 10.1016/S0022-2836(03)00845-3

Breithaupt, C., Schubart, A., Zander, H., Skerra, A., Huber, Robert, Linington, C. and Jacob, U. 2003. Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Proceedings of the National Academy of Sciences of the United States of America 100 (16) , pp. 9446-9451. 10.1073/pnas.1133443100

Gerhardt, Stefan, Echt, Stefanie, Busch, Marco, Freigang, Jorg, Auerbach, Gunter, Bader, Gerd, Martin, William F,, Bacher, Adelbert, Huber, Robert and Fischer, Markus 2003. Structure and properties of an engineered transketolase from maize. Plant Physiology 132 (4) , pp. 1941-1949. 10.1104/pp.103.020982

Blaesse, Michael, Kupke, Thomas, Huber, Robert and Steinbacher, Stefan 2003. Structure of MrsD, an FAD-binding protein of the HFCD family. Acta Crystallographica Section D: Biological Crystallography 59 (8) , pp. 1414-1421. 10.1107/S0907444903011831

Wendt, Kerstin S., Schall, Iris, Huber, Robert, Buckel, Wolfgang and Jacob, Uwe 2003. Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase. The EMBO Journal 22 (14) , pp. 3493-3502. 10.1093/emboj/cdg358

Henrich, Stefan, Cameron, Angus, Bourenkov, Gleb P., Kiefersauer, Reiner, Huber, Robert, Lindberg, Iris, Bode, Wolfram and Than, Manuel E 2003. The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nature Structural Biology 10 (7) , pp. 520-526. 10.1038/nsb941

Gaßel, Michael, Breitenlechner, Christine B., Rüger, Petra, Jucknischke, Ute, Schneider, Thorsten, Huber, Robert, Bossemeyer, Dirk and Engh, Richard A. 2003. Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT). Journal of Molecular Biology 329 (5) , pp. 1021-1034. 10.1016/S0022-2836(03)00518-7

Steinbacher, Stefan, Kaiser, Johannes, Gerhardt, Stefan, Eisenreich, Wolfgang, Huber, Robert, Bacher, Adelbert and Rohdich, Felix 2003. Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate Isomerase from bacillus subtilis. Journal of Molecular Biology 329 (5) , pp. 973-982. 10.1016/S0022-2836(03)00527-8

Hyun Bae, Jae, Rubini, Marina, Jung, Gregor, Wiegand, Georg, Seifert, Markus H. J., Azim, M. Kamran, Kim, Jeong-Sun, Zumbusch, Andreas, Holak, Tad A., Moroder, Luis, Huber, Robert and Budisa, Nediljko 2003. Expansion of the genetic code enables design of a novel 'gold' class of green fluorescent proteins. Journal of Molecular Biology 328 (5) , pp. 1071-1081. 10.1016/S0022-2836(03)00364-4

Augustin, Martin A, Reichert, Andreas S, Betat, Heike, Huber, Robert, Mörl, Mario and Steegborn, Clemens 2003. Crystal structure of the human CCA-adding enzyme: Insights into template-independent polymerization. Journal of Molecular Biology 328 (5) , pp. 985-994. 10.1016/S0022-2836(03)00381-4

Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, Robert, Bacher, A. and Rohdich, F. 2003. Structural basis of fosmidomycin action revealed by the complex with 2-C-Methyl-D-erythritol 4-phosphate synthase (IspC). Journal of Biological Chemistry 278 (20) , pp. 18401-1807. 10.1074/jbc.M300993200

Cunha, C. A., Macieira, S., Dias, J. M., Almeida, G., Goncalves, L. L., Costa, C., Lampreia, J., Huber, Robert, Moura, J. J. G., Moura, I. and Romao, M. J. 2003. Cytochrome c nitrite reductase from Desulfovibrio desulfuricans ATCC 27774. Journal of Biological Chemistry 278 (19) , pp. 17455-17465. 10.1074/jbc.M211777200

Groll, Michael and Huber, Robert 2003. Substrate access and processing by the 20S proteasome core particle. The International Journal of Biochemistry & Cell Biology 35 (5) , pp. 606-616. 10.1016/S1357-2725(02)00390-4

Engel, M., Hoffmann, T., Wagner, L., Wermann, M., Heiser, U., Kiefersauer, R., Huber, Robert, Bode, W., Demuth, H.-U. and Brandstetter, H. 2003. The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proceedings of the National Academy of Sciences of the United States of America 100 (9) , pp. 5063-5068. 10.1073/pnas.0230620100

Machius, M., Declerck, N., Huber, Robert and Wiegand, G. 2003. Kinetic stabilization of Bacillus licheniformis  a-amylase through introduction of hydrophobic residues at the surface. Journal of Biological Chemistry 278 (13) , pp. 11546-11553. 10.1074/jbc.M212618200

Steinbacher, Stefan, Hernández-Acosta, Pilar, Bieseler, Bastian, Blaesse, Michael, Huber, Robert, Culiáñez-Macià, Francisco Antonio and Kupke, Thomas 2003. Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate. Journal of Molecular Biology 327 (1) , pp. 193-202. 10.1016/S0022-2836(03)00092-5

Groll, Michael, Brandstetter, Hans, Bartunik, Hans, Bourenkow, Gleb and Huber, Robert 2003. Investigations on the maturation and regulation of archaebacterial proteasomes. Journal of Molecular Biology 327 (1) , pp. 75-83. 10.1016/S0022-2836(03)00080-9

Krapp, S., Mimura, Y., Jefferis, R., Huber, Robert and Sondermann, P. 2003. Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. Journal of Molecular Biology 325 (5) , pp. 979-989. 10.1016/S0022-2836(02)01250-0

Rebelo, Jorge, Auerbach, Günter, Bader, Gerd, Bracher, Andreas, Nar, Herbert, Hösl, Cornelia, Schramek, Nicholas, Kaiser, Johannes, Bacher, Adelbert, Huber, Robert and Fischer, Markus 2003. Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. Journal of Molecular Biology 326 (2) , pp. 503-513. 10.1016/S0022-2836(02)01303-7

Fischer, Markus, Haase, Ilka, Kis, Klaus, Meining, Winfried, Ladenstein, Rudolf, Cushman, Mark, Schramek, Nicholas, Huber, Robert and Bacher, Adelbert 2003. Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-Dimethyl-8-ribityllumazine synthase. Journal of Molecular Biology 326 (3) , pp. 783-793. 10.1016/S0022-2836(02)01473-0

Messerschmidt, A., Worbs, M., Steegborn, C., Wahl, M.C., Huber, Robert, Laber, B. and Clausen, T. 2003. Determinants of enzymatic specificity in the cys-met-metabolism PLP-dependent enzyme family: crystal structure of cystathionine γ-lyase from yeast and intrafamiliar structure comparison. Biological Chemistry 384 (3) , pp. 373-386. 10.1515/BC.2003.043

Krojer, Tobias, Garrido-Franco, Marta, Huber, Robert, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Clausen, Tim 2002. Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature Nature , pp. 455-459. 10.1038/416455a

Kaiser, J. T., Bruno, S., Clausen, T., Huber, Robert, Schiaretti, F., Mozzarelli, A. and Kessler, D. 2002. Snapshots of the cystine lyase C-DES during catalysis. Journal of Biological Chemistry 278 (1) , pp. 357-365. 10.1074/jbc.M209862200

Song, Hyun Kyu, Bochtler, Matthias, Azim, M. Kamran, Hartmann, Claudia, Huber, Robert and Ramachandran, Ravishankar 2002. Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV. Biophysical Chemistry 100 (1-3) , pp. 437-457. 10.1016/S0301-4622(02)00297-1

Sichler, Katrin, Kopetzki, Erhard, Huber, Robert, Bode, Wolfram, Hopfner, Karl-Peter and Brandstetter, Hans 2002. Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop. Journal of Biological Chemistry 278 (6) , pp. 4121-4125. 10.1074/jbc.M210722200

Brandstetter, Hans, Kim, Jeong-Sun, Groll, Michael and Huber, Robert 2001. Crystal structure of the tricorn protease reveals a protein dissassembly line. Nature , pp. 466-470. 10.1038/35106609