Browse by Current Cardiff authors

Sternsdorf, Thomas, Puccetti, Elena, Jensen, Kirsten, Hoelzer, Dieter, Will, Hans, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2023. PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Molecular and Cellular Biology 19 (7) , pp. 5170-5178. 10.1128/mcb.19.7.5170

Müller-Tidow, Carsten, Steffen, Björn, Cauvet, Thomas, Tickenbrock, Lara, Ji, Ping, Diederichs, Sven, Sargin, Bülent, Köhler, Gabriele, Stelljes, Matthias, Puccetti, Elena, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, deVos, Sven, Hiebert, Scott W., Koeffler, H. Phillip, Berdel, Wolfgang E. and Serve, Hubert 2023. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Molecular and Cellular Biology 24 (7) , pp. 2890-2904. 10.1128/MCB.24.7.2890-2904.2004

Chiriches, Claudia ORCID: https://orcid.org/0000-0003-3758-1892, Khan, Dilawar, Wieske, Maria, Guillen, Nathalie, Rokicki, Michal, Guy, Carol, Wilson, Marieangela, Heesom, Kate J., Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2022. Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia. Annals of Hematology 101 , pp. 2179-2193. 10.1007/s00277-022-04905-9

Chiriches, Claudia ORCID: https://orcid.org/0000-0003-3758-1892, Nicolaisen, Nathalie, Wieske, Maria, Elhaddad, Heba, Mehmetbeyoglu, Ecmel, Alvares, Caroline ORCID: https://orcid.org/0000-0003-4391-9802, Becher, Dörte, Hole, Paul, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2022. Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation. PLoS Genetics 18 (10) , e1010463. 10.1371/journal.pgen.1010463

Mian, Afsar Ali, Haberbosch, Isabella, Khamaisie, Hazem, Agbarya, Abed, Pietsch, Larissa, Eshel, Elizabeh, Najib, Dally, Chiriches, Claudia ORCID: https://orcid.org/0000-0003-3758-1892, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330, Hantschel, Oliver, Biondi, Ricardo M., Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahajna, Jamal 2021. Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR/ABL1 and its resistance and compound mutants BCR/ABL1T315I and BCR/ABL1T315I-E255K. Annals of Hematology 100 , pp. 2023-2029. 10.1007/s00277-020-04357-z

Regev, Ofer, Kidan, Noa, Nicola, Meshel, Khamisie, Hazem, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahajna, Jamal 2021. Mesenchymal soluble factors confer imatinib drug resistance in chronic myelogenous leukemia cells. Archives of Medical Science 17 (1) , 266–274. 10.5114/aoms.2020.101042

Oancea, C, Rüster, B, Henschler, R, Puccetti, E and Ruthardt, M ORCID: https://orcid.org/0000-0003-1021-3811 2020. The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation. Leukemia 24 , 1910–1919. 10.1038/leu.2010.180

Mian, Afsar A., Baumann, Ines, Liebermann, Marcus, Grebien, Florian, Superti-Furga, Giulio, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330 and Hantschel, Oliver 2019. The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis. Leukemia 33 , pp. 2319-2323. 10.1038/s41375-019-0468-y

Kidan, Noa, Khamaisie, Hazem, Ruimi, Nili, Roitman, Shay, Eshel, Elizabeth, Dally, Najib, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahajna, Jamal 2017. Ectopic expression of snail and twist in Ph+ leukemia cells upregulates CD44 expression and alters their differentiation potential. Journal of Cancer 8 (19) , pp. 3952-3968. 10.7150/jca.19633

Ratzon, Einav, Najajreh, Yousef, Salem, Rami, Khamaisie, Hazem, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahajna, Jamal 2016. Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study. BMC Cancer 16 , 140. 10.1186/s12885-016-2182-8

Haberbosch, Isabella, Rafiei, Anahita, Oancea, Claudia ORCID: https://orcid.org/0000-0003-3758-1892, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mian, Afsar 2016. BCR: a new target in resistance mediated by BCR/ABL-315I? Genes & Cancer 7 (1-2) , pp. 36-46.

Mian, A. A., Rafiei, A., Haberbosch, I., Zeifman, A., Titov, I., Stroylov, V., Metodieva, A., Stroganov, O., Novikov, F., Brill, B., Chilov, G., Hoelzer, D., Ottmann, O. G. ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, M. ORCID: https://orcid.org/0000-0003-1021-3811 2015. PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation. Leukemia 29 (5) , pp. 1104-1114. 10.1038/leu.2014.326

Rafiei, Anahita, Mian, Afsar Ali, Doering, Claudia, Metodieva, Anna, Oancea, Claudia ORCID: https://orcid.org/0000-0003-3758-1892, Thalheimer, Frederic B., Hansmann, Martin Leo, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2015. The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive Acute Lymphatic Leukemia. PLOS Genetics 11 (4) , e1005144. 10.1371/journal.pgen.1005144

Mian, Afsar A., Haberboseh, Isabella, Kidan, Noa, Khamaisic, Hazem, Regev, Ofer, Nickola, Meshel, Gal, Maayan, Bloch, Etai, Ratiei, Anahita, Silani, Daryuseh, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330, Biondi, Ricardo, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahaina, Jamal 2015. Potential use of allosteric inhibitors as strategy to overcome drug resistance in Ph-positive leukemia. International Journal of Molecular Medicine 36 , S26-S26.

Mian, Afsar, Rafiei, Anahita, Oancea, Claudia ORCID: https://orcid.org/0000-0003-3758-1892, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2014. The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome positive Acute Lymphatic Leukemia. Blood 124 (21) , 2402.

Oancea, Claudia, Rüster, Brigitte, Brill, Boris, Roos, Jessica, Heinssmann, Maria, Bug, Gesine, Mian, Afsar Ali, Guillen, Nathalie Andrea, Kornblau, Steven M., Henschler, Reinhard and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2014. STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML. Genes & Cancer 5 (11-12) , pp. 378-392. 10.18632/genesandcancer.39

Roos, Jessica, Oancea, Claudia, Heinssmann, Maria, Khan, Dilawar, Held, Hannelore, Kahnt, Astrid S., Capelo, Ricardo, la Buscato, Estel, Proschak, Ewgenij, Puccetti, Elena, Steinhilber, Dieter, Fleming, Ingrid, Maier, Thorsten J. and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2014. 5-lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia. Cancer Research 74 (18) , pp. 5244-5255. 10.1158/0008-5472.CAN-13-3012

Badura, Susanne, Tesanovic, Tamara, Pfeifer, Heike, Wystub, Sylvia, Nijmeijer, Bart A., Liebermann, Marcus, Falkenburg, J. H. Frederik, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330 2013. Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia. PLOS ONE 8 (11) , e80070. 10.1371/journal.pone.0080070

Najajreh, Yousef, Khamaisie, Hazem, Ruimi, Nili, Khatib, Soliman, Katzhendler, Joshua, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahajna, Jamal 2013. Oleylamine-carbonyl-valinol inhibits auto-phosphorylation activity of native and T315I mutated Bcr-Abl, and exhibits selectivity towards oncogenic Bcr-Abl in SupB15 ALL cell lines. Molecular Biology Reports 40 , 2205–2213. 10.1007/s11033-012-2282-8

Khateb, Mamduh, Ruimi, Nili, Khamisie, Hazem, Najajreh, Yousef, Mian, Afsar, Metodieva, Anna, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahajna, Jamal 2012. Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism. BMC Cancer 12 , 563. 10.1186/1471-2407-12-563

Mian, Afsar Ali, Metodieva, Anna, Badura, Susanne, Khateb, Mamduh, Ruimi, Nili, Najajreh, Yousef, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330, Mahajna, Jamal and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2012. Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I. BMC Cancer 12 (411) 10.1186/1471-2407-12-411

Romanski, Annette, Schwarz, Kerstin, Keller, Maren, Wietbrauk, Sarah, Vogel, Anja, Roos, Jessica, Oancea, Claudia, Brill, Boris, Krämer, Oliver H., Serve, Hubert, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Bug, Gesine 2012. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle 11 (17) , pp. 3219-3226. 10.4161/cc.21565

Mian, Afsar A., Metodieva, Anna, Najajreh, Yousef, Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330, Mahajna, Jamal and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2012. p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia. Haematologica 97 (2) 10.3324/haematol.2011.047191

Rettinger, Eva, KuçI, Selim, Naumann, Ivonne, Becker, Petra, Kreyenberg, Hermann, Anzaghe, Martina, Willasch, Andre, Koehl, Ulrike, Bug, Gesine, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Klingebiel, Thomas, Fulda, Simone and Bader, Peter 2012. The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells. Cytotherapy 14 (1) , pp. 91-103. 10.3109/14653249.2011.613931

Steinert, Gunnar, Oancea, Claudia, Roos, Jessica, Hagemeyer, Heike, Maier, Thorsten, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Puccetti, Elena 2011. Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα. PLoS ONE 6 (7) , e22540. 10.1371/journal.pone.0022540

Khamaisie, Hazem, Sussan, Sherbel, Tal, Michael, Najajreh, Yousef, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Mahajna, Jamal 2011. Oleic acid is the active component in the mushroom Daedalea gibbosa inhibiting Bcr-Abl kinase autophosphorylation activity. Anticancer Research 31 (1) , pp. 177-183.

Steinhilber, Dieter, Fischer, Astrid Stefanie, Metzner, Julia, Steinbrink, Svenja Dorothea, Roos, Jessica, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Maier, Thorsten Jürgen 2010. 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis. Frontiers in Pharmacology 1 (143) 10.3389/fphar.2010.00143

Bursen, Adelheid, Schwabe, Karen, Rüster, Brigitte, Henschler, Reinhard, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Dingermann, Theo and Marschalek, Rolf 2010. The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4. Blood 115 (17) , 3570–3579. 10.1182/blood-2009-06-229542

Mian, A A, Oancea, C, Zhao, Z, Ottmann, O G ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, M ORCID: https://orcid.org/0000-0003-1021-3811 2009. Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL. Leukemia 23 , 2242–2247. 10.1038/leu.2009.194

Zheng, Xiaomin, Oancea, Claudia, Henschler, Reinhard, Moore, Malcolm A. S. and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2009. Reciprocal t(9;22) ABL/BCR fusion proteins: Leukemogenic potential and effects on B cell commitment. PLoS ONE 4 (10) , e7661. 10.1371/journal.pone.0007661

Mian, A A, Schüll, M, Zhao, Z, Oancea, C, Hundertmark, A, Beissert, T, Ottmann, O G ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, M ORCID: https://orcid.org/0000-0003-1021-3811 2009. The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL. Leukemia 23 , 1614–1621. 10.1038/leu.2009.69

Boehrer, Simone, Chow, Kai U., Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Hoelzer, Dieter, Mitrou, Paris S. and Weidmann, Eckhart 2009. Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells. Leukemia & Lymphoma 43 (9) , pp. 1737-1741. 10.1080/1042819021000006510

Zheng, Xiaomin, Oancea, Claudia, Henschler, Reinhard and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2009. Cooperation between constitutively activated c-kit signaling and leukemogenic transcription factors in the determination of the leukemic phenotype in murine hematopoietic stem cells. International Journal of Oncology 34 (6) , pp. 1521-1531. 10.3892/ijo_00000281

Gwanmesia, Patricia Mambou, Romanski, Annette, Schwarz, Kerstin, Bacic, Biserka, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Ottmann, Oliver G ORCID: https://orcid.org/0000-0001-9559-1330 2009. The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines. BMC Cancer 9 , 53. 10.1186/1471-2407-9-53

Beissert, Tim, Hundertmark, Alena, Kaburova, Velina, Travaglini, Lorena, Mian, Afsar A., Nervi, Clara and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2008. Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL. International Journal of Cancer 122 (12) , pp. 2744-2752. 10.1002/ijc.23467

Bug, Gesine, Schwarz, Kerstin, Schoch, Claudia, Kampfmann, Manuela, Henschler, Reinhard, Hoelzer, Dieter, Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2007. Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia. Haematologica 92 (4) 10.3324/haematol.10758

Zheng, Xiaomin, Seshire, Anita, Rüster, Brigitte, Bug, Gesine, Beissert, Tim, Puccetti, Elena, Hoelzer, Dieter, Henschler, Reinhard and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2007. Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells. Haematologica 92 (3) 10.3324/haematol.10541

Yokota, Asumi, Kimura, Shinya, Masuda, Satohiro, Ashihara, Eishi, Kuroda, Junya, Sato, Kiyoshi, Kamitsuji, Yuri, Kawata, Eri, Deguchi, Yasuyuki, Urasaki, Yoshimasa, Terui, Yasuhito, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Ueda, Takanori, Hatake, Kiyohiko, Inui, Ken-ichi and Maekawa, Taira 2007. INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity. Blood 109 (1) , 306–314. 10.1182/blood-2006-03-013250

Zheng, Xiaomin, Güller, Saskia, Beissert, Tim, Puccetti, Elena and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2006. BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility. BMC Cancer 6 , 262. 10.1186/1471-2407-6-262

Boehrer, Simone, Nowak, Daniel, Puccetti, Elena, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Sattler, Nicole, Trepohl, Bettina, Schneider, Bernd, Hoelzer, Dieter, Mitrou, Paris S. and Chow, Kai Uwe 2006. Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis. Leukemia Research 30 (5) , pp. 597-605. 10.1016/j.leukres.2005.09.003

Bug, Gesine, Ritter, Markus, Wassmann, Barbara, Schoch, Claudia, Heinzel, Thorsten, Schwarz, Kerstin, Romanski, Annette, Kramer, Oliver H., Kampfmann, Manuela, Hoelzer, Dieter, Neubauer, Andreas, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330 2005. Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia. Cancer 104 (12) , pp. 2717-2725. 10.1002/cncr.21589

Puccetti, Elena, Zheng, Xiaomin, Brambilla, Daria, Seshire, Anita, Beissert, Tim, Boehrer, Simone, Nürnberger, Heike, Hoelzer, Dieter, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330, Nervi, Clara and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2005. The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha. Cancer Research 65 (14) , 6080–6088. 10.1158/0008-5472.CAN-04-3631

Pramanik, Kallal, Trüpschuch, Sandra, Greiner, Axel, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Henschler, Reinhard and Müller, Albrecht M. 2005. The aorta-gonad-mesonephros-derived stroma cell line DAS104-4 induces differentiation of leukemic cells. Leukemia Research 32 (5) , pp. 781-789. 10.1016/j.leukres.2007.09.014

Bug, Gesine, Gül, Hilal, Schwarz, Kerstin, Pfeifer, Heike, Kampfmann, Manuela, Zheng, Xiaomin, Beissert, Tim, Boehrer, Simone, Hoelzer, Dieter, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2005. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Research 65 (7) , 2537–2541. 10.1158/0008-5472.CAN-04-3011

Boehrer, Simone, Brieger, Angela, Schaaf, Simone, Kukoc-Zivojnov, Natasa, Nowak, Daniel, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Hoelzer, Dieter, Mitrou, Paris S, Weidmann, Eckhart and Chow, Kai Uwe 2004. In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. Leukemia & Lymphoma 45 (7) , pp. 1445-1451. 10.1080/10428190410001663617

Kukoc-Zivojnov, Natasa, Puccetti, Elena, Chow, Kai U, Bergmann, Marion, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Hoelzer, Dieter, Mitrou, Paris S, Weidmann, Eckhart and Boehrer, Simone 2004. Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells. Experimental Hematology 32 (7) , pp. 649-656. 10.1016/j.exphem.2004.04.004

Puccetti, E and Ruthardt, M ORCID: https://orcid.org/0000-0003-1021-3811 2004. Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell. Leukemia 18 , 1169–1175. 10.1038/sj.leu.2403367

Brieger, Angela, Boehrer, Simone, Schaaf, Simone, Nowak, Daniel, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Kim, Soo-Zin, Atadja, Peter, Hoelzer, Dieter, Mitrou, Paris S, Weidmann, Eckhart and Chow, Kai Uwe 2004. In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. Biochemical Pharmacology 68 (1) , pp. 85-93. 10.1016/j.bcp.2004.02.028

Zheng, Xiaomin, Beissert, Tim, Kukoc-Zivojnov, Natasa, Puccetti, Elena, Altschmied, Joachim, Strolz, Corinna, Boehrer, Simone, Gul, Hilal, Schneider, Orinta, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330, Hoelzer, Dieter, Henschler, Reinhard and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2004. Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells. Blood 103 (9) , 3535–3543. 10.1182/blood-2003-09-3335

Zang, Chuanbing, Liu, Hongyu, Posch, Maximilian G, Waechter, Maries, Facklam, Margit, Fenner, Martin H, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Possinger, Kurt, Koeffler, H Phillip and Elstner, Elena 2004. Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. Leukemia Research 28 (4) , pp. 387-397. 10.1016/j.leukres.2003.07.005

Romanski, Annette, Bacic, Biserka, Bug, Gesine, Pfeifer, Heike, Gul, Hilal, Remiszewski, Stacy, Hoelzer, Dieter, Atadja, Peter, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 and Ottmann, Oliver G ORCID: https://orcid.org/0000-0001-9559-1330 2004. Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. Haematologica 89 (4) , pp. 419-426.

Beissert, Tim, Puccetti, Elena, Bianchini, Andrea, Güller, Saskia, Boehrer, Simone, Hoelzer, Dieter, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330, Nervi, Clara and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2003. Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571. Blood 102 (8) , 2985–2993. 10.1182/blood-2003-03-0811

Puccetti, Elena, Beissert, Tim, Güller, Saskia, Li, Jun E, Hoelzer, Dieter, Ottmann, Oliver G ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2003. Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis. Oncogene 22 , 6900–6908. 10.1038/sj.onc.1206747

Chow, Kai Uwe, Nowak, Daniel, Boehrer, Simone, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Knau, Andrea, Hoelzer, Dieter, Mitrou, Paris S. and Weidmann, Eckhart 2003. Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochemical Pharmacology 66 (5) , pp. 711-724. 10.1016/S0006-2952(03)00410-6

Puccetti, Elena, Obradovic, Darja, Beissert, Tim, Bianchini, Andrea, Washburn, Birgit, Chiaradonna, Ferdinando, Boehrer, Simone, Hoelzer, Dieter, Ottmann, Oliver Gerhard ORCID: https://orcid.org/0000-0001-9559-1330, Pelicci, Pier Giuseppe, Nervi, Clara and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2002. AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor. Cancer Research 62 (23) , 7050–7058.

Möller, Burkhard, Kukoc-Zivojnov, Natasa, Okamgba, Stella, Kessler, Uta, Puccetti, Elena, Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330, Kaltwasser, Joachim P., Hoelzer, Dieter and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2002. Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors. Rheumatology International 22 , 60–67. 10.1007/s00296-002-0188-9

Maurer, Alexander B., Wichmann, Christian, Gross, Alexandra, Kunkel, Hana, Heinzel, Thorsten, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Groner, Bernd and Grez, Manuel 2002. The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex. Blood 99 (8) , 2647–2652. 10.1182/blood.V99.8.2647

Boehrer, Simone, Chow, Kai U., Beske, Florian, Kukoc-Zivojnov, Natasa, Puccetti, Elena, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Baum, Christine, Rangnekar, Vivek M., Hoelzer, Dieter, Mitrou, Paris S. and Weidmann, Eckhart 2002. In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation. Cancer Research 62 (6) , 1768–1775.

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Nervi, Clara, Ferrara, Fabiana F., Fanelli, Mirco, Rippo, Maria Rita, Tomassini, Barbara, Ferrucci, Pier Francesco, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Gelmetti, Vania, Gambacorti-Passerini, Carlo, Diverio, Daniela, Grignani, Francesco, Pelicci, Pier Giuseppe and Testi, Roberto 1998. Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein. Blood 92 (7) , pp. 2244-2251. 10.1182/blood.V92.7.2244

Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Orleth, Annette, Tomassoni, Lucia, Puccetti, Elena, Riganelli, Daniela, Alcalay, Myriam, Mannucci, Roberta, Nicoletti, Ildo, Grignani, Francesco, Fagioli, Marta and Pelicci, Pier Giuseppe 1998. The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. Oncogene 16 , 1945–1953. 10.1038/sj.onc.1201722

He, Li-Zhen, Guidez, Fabien, Tribioli, Carla, Peruzzi, Daniela, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Zelent, Arthur and Pandolfi, Pier Paolo 1998. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nature Genetics 18 , 126–135. 10.1038/ng0298-126

Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Testa, Ugo, Nervi, Clara, Ferrucci, Pier Francesco, Grignani, Francesco, Puccetti, Elena, Grignani, Fausto, Peschle, Cesare and Pelicci, Pier Giuseppe 1997. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling. Molecular and Cellular Biology 17 (8) , pp. 4859-4869. 10.1128/MCB.17.8.4859

Benedetti, Laura, Levin, Arthur A., Scicchitano, Bianca M., Grignani, Francesco, Allenby, Gary, Diverio, Daniela, Lo Coco, Francesco, Avvisati, Giuseppe, Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811, Adamo, Sergio, Pelicci, Pier Giuseppe and Nervi, Clara 1997. Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells. Blood 90 (3) , pp. 1175-1185. 10.1182/blood.V90.3.1175

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