The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice

Michael, D. R., Davies, T. S., Moss, J. W. E., Calvente, D. Lama, Ramji, D. P. ORCID: https://orcid.org/0000-0002-6419-5578, Marchesi, J. R. ORCID: https://orcid.org/0000-0002-7994-5239, Pechlivanis, A., Plummer, S. F. and Hughes, T. R. ORCID: https://orcid.org/0000-0003-2348-3490 2017. The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice. Scientific Reports 7 , 2883. 10.1038/s41598-017-02889-5

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Abstract

Hypercholesterolaemia is a major risk factor for cardiovascular disease and it has been found that some probiotic bacteria possess cholesterol-lowering capabilities. In this study, the ability of the Lab4 probiotic consortium to hydrolyse bile salts, assimilate cholesterol and regulate cholesterol transport by polarised Caco-2 enterocytes was demonstrated. Furthermore, in wild-type C57BL/6J mice fed a high fat diet, 2-weeks supplementation with Lab4 probiotic consortium plus Lactobacillusplantarum CUL66 resulted in significant reductions in plasma total cholesterol levels and suppression of diet-induced weight gain. No changes in plasma levels of very low-density lipoprotein/low-density lipoprotein, high-density lipoprotein, triglycerides, cytokines or bile acids were observed. Increased amounts of total and unconjugated bile acids in the faeces of the probiotic-fed mice, together with modulation of hepatic small heterodimer partner and cholesterol-7α-hydroxylase mRNA expression, implicates bile salt hydrolase activity as a potential mechanism of action. In summary, this study demonstrates the cholesterol-lowering efficacy of short-term feeding of the Lab4 probiotic consortium plus L. plantarum CUL66 in wild-type mice and supports further assessment in human trials.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License.
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date of First Compliant Deposit:	6 June 2017
Date of Acceptance:	19 April 2017
Last Modified:	05 May 2023 03:33
URI:	https://orca.cardiff.ac.uk/id/eprint/101183

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