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Number of items: 48.

Carpanini, Sarah M., Torvell, Megan, Bevan, Ryan J., Byrne, Robert A. J., Daskoulidou, Nikoleta, Saido, Takaomi C., Taylor, Philip R., Hughes, Timothy R., Zelek, Wioleta M. and Morgan, B. Paul 2022. Terminal complement pathway activation drives synaptic Loss in Alzheimer’s disease models. Acta Neuropathologica Communications 10 , 99. 10.1186/s40478-022-01404-w

Webberley, Thomas S., Masetti, Giulia, Bevan, Ryan J., Kerry-Smith, Joshua, Jack, Alison A., Michael, Daryn R., Thomas, Sophie, Glymenaki, Maria, Li, Jia, McDonald, Julie A. K., John, Daniel, Morgan, James E., Marchesi, Julian R., Good, Mark A., Plummer, Sue F. and Hughes, Timothy R. 2022. The impact of probiotic supplementation on cognitive, pathological and metabolic markers in a transgenic mouse model of Alzheimer’s Disease. Frontiers in Neuroscience 16 , 843105. 10.3389/fnins.2022.843105

Westacott, Laura J., Humby, Trevor, Haan, Niels, Brain, Sophie A., Bush, Emma-Louise, Toneva, Margarita, Baloc, Andreea-Ingrid, Moon, Anna L., Reddaway, Jack, Owen, Michael J., Hall, Jeremy, Hughes, Timothy R., Morgan, B. Paul, Gray, William P. and Wilkinson, Lawrence S. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99 , pp. 70-82. 10.1016/j.bbi.2021.09.005

Westacott, Laura J., Haan, Niels, Evison, Claudia, Marei, Omar, Hall, Jeremy, Hughes, Timothy R., Zaben, Malik, Morgan, B. Paul, Humby, Trevor, Wilkinson, Lawrence S. and Gray, William P. 2021. Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice. Brain, Behavior, and Immunity 98 , pp. 136-150. 10.1016/j.bbi.2021.08.215

Baker, L.M., Webberley, T.S., Masetti, G., Hughes, T.R., Marchesi, J.R., Jack, A.A., Joyce, T.S.C., Allen, M.D., Plummer, S.F., Michael, D.R., Ramanathan, G., Del Sol, R. and Facey, P.D. 2021. A genome guided evaluation of the Lab4 probiotic consortium. Genomics 113 (6) , pp. 4028-4038. 10.1016/j.ygeno.2021.08.007

Webberley, Thomas S., Masetti, Giulia, Baker, Laura M., Dally, Jordanna, Hughes, Timothy R., Marchesi, Julian R., Jack, Alison A., Plummer, Sue F., Ramanathan, Guru, Facey, Paul D. and Michael, Daryn R. 2021. The impact of Lab4 probiotic supplementation in a 90-Day study in wistar rats. Frontiers in Nutrition 8 , 778289. 10.3389/fnut.2021.778289

Al-Ahmadi, Wijdan, Webberley, Thomas S., Joseph, Alex, Harris, Ffion, Chan, Yee-Hung, Alotibi, Reem, Williams, Jessica O., Alahmadi, Alaa, Decker, Thomas, Hughes, Timothy R. and Ramji, Dipak P. 2021. Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation. FASEB Journal 35 (10) , e21892. 10.1096/fj.202100571RR

Moss, Joe W. E., Williams, Jessica O., Al-Ahmadi, Wijdan, O'Morain, Victoria, Chan, Yee-Hung, Hughes, Timothy R., Menendez-Gonzalez, Juan B., Almotiri, Alhomidi, Plummer, Sue F., Rodrigues, Neil P., Michael, D. R. and Ramji, Dipak P. 2021. Protective effects of a unique combination of nutritionally active ingredients on risk factors and gene expression associated with atherosclerosis in C57BL/6J mice fed a high fat diet. Food and Function 12 (8) , pp. 3657-3671. 10.1039/D0FO02867C

Mullish, Benjamin H., Marchesi, Julian R., McDonald, Julie A. K., Pass, Daniel A., Masetti, Giulia, Michael, Daryn R., Plummer, Sue, Jack, Alison A., Davies, Thomas S., Hughes, Timothy R. and Wang, Duolao 2021. Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics? Gut Microbes 13 (1) , pp. 1-9. 10.1080/19490976.2021.1900997

Bevan, Ryan J., Hughes, Tim R., Williams, Pete A., Good, Mark A., Morgan, B. Paul and Morgan, James E. 2020. Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease. Acta Neuropathologica Communications 8 (1) , 216. 10.1186/s40478-020-01094-2

Michael, D. R., Jack, A. A., Masetti, G., Davies, T. S., Loxley, K. E., Kerry-Smith, J., Plummer, J. F., Marchesi, J. R., Mullish, B. H., McDonald, J. A. K., Hughes, T. R., Wang, D., Garaiova, I., Paduchová, Z., Muchová, J., Good, M. A. and Plummer, S. F. 2020. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being. Scientific Reports 10 (1) , -. 10.1038/s41598-020-60991-7

Michael, D.R., Davies, T.S., Loxley, K.E., Allen, M.D., Good, M.A., Hughes, T.R. and Plummer, S.F. 2019. In vitro neuroprotective activities of two distinct probiotic consortia. Beneficial Microbes 10 (4) , pp. 437-447. 10.3920/BM2018.0105

Boshra, Hani, Zelek, Wioleta M., Hughes, Timothy R., Rodriguez de Cordoba, Santiago and Morgan, B. Paul 2018. Absence of CD59 in guinea pigs: Analysis of the Cavia porcellus genome suggests the evolution of a CD59 pseudogene. Journal of Immunology 200 (1) , pp. 327-335. 10.4049/jimmunol.1701238

Michael, D. R., Davies, T. S., Moss, J. W. E., Calvente, D. Lama, Ramji, D. P., Marchesi, J. R., Pechlivanis, A., Plummer, S. F. and Hughes, T. R. 2017. The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice. Scientific Reports 7 , 2883. 10.1038/s41598-017-02889-5

Bergfeld, Arne, Dasari, Prasad, Werner, Sandra, Hughes, Timothy, Song, Wen-Chao, Hortschansky, Peter, Brakhage, Axel A., Hünig, Thomas, Zipfel, Peter F. and Beyersdorf, Niklas 2017. Direct binding of the pH-regulated protein 1 (Pra1) from Candida albicans inhibits cytokine secretion by mouse CD4+ T cells. Frontiers in Microbiology 8 10.3389/fmicb.2017.00844

Granados-Durán, Pablo, López-Ávalos, María Dolores, Cifuentes, Manuel, Pérez-Martín, Margarita, Fernández-Arjona, María del Mar, Hughes, Timothy, Johnson, Krista, Morgan, Bryan, Fernández-Llebrez, Pedro and Grondona, Jesús M. 2017. Microbial neuraminidase induces a moderate and transient myelin vacuolation independent of complement system activation. Frontiers in Neurology 8 , 78. 10.3389/fneur.2017.00078

Granados-Duran, Pablo, Lopez-Avalos, Maria Dolores, Hughes, Timothy Richard, Johnson, Krista, Morgan, Bryan Paul, Tamburini, Paul P., Fernandez-Llebrez, Pedro and Grondona, Jesus M. 2016. Complement system activation contributes to the ependymal damage induced by microbial neuraminidase. Journal of Neuroinflammation 13 (115) 10.1186/s12974-016-0576-9

Towner, Laurence D., Wheat, Richard A., Hughes, Timothy R. and Morgan, B. Paul 2016. Complement membrane attack and tumorigenesis: a systems biology approach. Journal of Biological Chemistry 291 (29) , pp. 14927-14938. 10.1074/jbc.M115.708446

Bloom, Anja C., Collins, Fraser L., van't Hof, Rob J., Ryan, Elizabeth S., Jones, Emma, Hughes, Timothy R., Morgan, B. Paul, Erlandsson, Malin, Bokarewa, Maria, Aeschlimann, Daniel, Evans, Bronwen A. J. and Williams, Anwen S. 2016. Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice. Bone 84 , pp. 253-261. 10.1016/j.bone.2015.12.014

Triantafilou, Martha, Hughes, Timothy, Morgan, Bryan and Triantafilou, Kathy 2016. Complementing the inflammasome. Immunology 147 (2) , pp. 152-164. 10.1111/imm.12556

McCully, Michelle L., Collins, Paul J., Hughes, Timothy R., Thomas, Christopher P., Billen, Jaak, O'Donnell, Valerie B. and Moser, Bernhard 2015. Skin metabolites define a new paradigm in the localization of skin tropic memory T cells. Journal of Immunology 195 (1) , pp. 96-104. 10.4049/jimmunol.1402961

Ramaglia, V., Jackson, S. J., Hughes, Timothy, Neal, James, Baker, D. and Morgan, Bryan 2015. Complement activation and expression during chronic relapsing experimental autoimmune encephalomyelitis in the Biozzi ABH mouse. Clinical & Experimental Immunology 180 (3) , pp. 432-441. 10.1111/cei.12595

Davies, T. S., Gallagher, H., Jaafar, F., Moss, J. W., Hughes, Timothy Rutland and Ramji, Dipak Purshottam 2015. Interferon gamma signalling in atherosclerosis: pro-atherogenic actions and therapeutic approaches. Cardiology 131 , p. 292.

Towner, Laurence, Hughes, Timothy and Morgan, B. Paul 2014. Exploring the effects of non-lethal complement membrane attack on CT26 Colon Carcinoma cells using network analysis of differentially expressed genes. Molecular Immunology 61 (2) , pp. 245-246.

Davies, T. S., Li, N., McLaren, James, Hughes, Timothy Richard and Ramji, Dipak Purshottam 2014. Pro- therogenic actions of interferon-gamma on macrophages in atherosclerosis. Cardiology 128 (S1) , p. 278. 10.1159/000365062

Steiner, Tanja, Francescut, Lorenza, Byrne, Simon, Hughes, Timothy Richard, Jayanthi, Archana, Guschina, Irina, Harwood, Adrian John, Cianflone, Katherine, Stover, Cordula and Francis, Sheila 2014. Protective role for properdin in progression of experimental murine atherosclerosis. PLoS ONE 9 (3) , e92404. 10.1371/journal.pone.0092404

Triantafilou, K., Hughes, T. R., Triantafilou, M. and Morgan, B. P. 2013. The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. Journal of Cell Science 126 (13) , pp. 2903-2913. 10.1242/jcs.124388

Laudisi, F., Spreafico, R., Evrard, M., Hughes, Timothy Richard, Mandriani, B., Kandasamy, M., Morgan, Bryan Paul, Sivasankar, B. and Mortellaro, A. 2013. Cutting edge: The NLRP3 inflammasome links complement-mediated inflammation and IL-1β release. The Journal of Immunology 191 (3) , pp. 1006-1010. 10.4049/jimmunol.1300489

Killick, R., Hughes, Timothy Richard, Morgan, Bryan Paul and Lovestone, S. 2013. Corrigendum to “Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH” [Neurosci. Lett. 533 (2013) 96–99] [Corrigendum]. Neuroscience Letters 545 , p. 144. 10.1016/j.neulet.2013.05.004

Killick, R., Hughes, Timothy Richard, Morgan, Bryan Paul and Lovestone, S. 2013. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neuroscience Letters 533 , pp. 96-99. 10.1016/j.neulet.2012.11.008

Kandasamy, Matheswaran, Ying, Poon C., Ho, Adrian W. S., Sumatoh, Hermi R., Schlitzer, Andreas, Hughes, Timothy Richard, Kemeny, David M., Morgan, Bryan Paul, Ginhoux, Florent and Sivasankar, Baalasubramanian 2013. Complement mediated signaling on pulmonary CD103+ dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathogens 9 (1) , e1003115. 10.1371/journal.ppat.1003115

Ramaglia, Valeria, Hughes, Timothy Richard, Donev, Rossen Mintchev, Ruseva, Marieta Milkova, Wu, Xiaobo, Huitinga, Inge, Baas, Frank, Neal, James William and Morgan, Bryan Paul 2012. C3-dependent mechanism of microglial priming relevant to multiple sclerosis. Proceedings of the National Academy of Sciences 109 (3) , pp. 965-970. 10.1073/pnas.1111924109

Lewis, Ruth D., Perry, Mark J., Guschina, Irina, Jackson, Christopher L., Morgan, Bryan Paul and Hughes, Timothy Richard 2011. CD55 deficiency protects against atherosclerosis in ApoE-deficient mice via C3a modulation of lipid metabolism. American Journal of Pathology 179 (4) , pp. 1601-1607. 10.1016/j.ajpath.2011.06.015

Lueck, K., Wasmuth, S., Williams, J., Hughes, Timothy Richard, Morgan, Bryan Paul, Lommatzsch, A., Greenwood, J., Moss, Sarah E. and Pauleikhoff, D. 2011. Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration. Eye 25 (8) , pp. 1074-1082. 10.1038/eye.2011.109

Lewis, Ruth D., Jackson, Christopher L., Morgan, Bryan Paul and Hughes, Timothy Richard 2010. The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. Molecular Immunology 47 (5) , pp. 1098-1105. 10.1016/j.molimm.2009.10.035

Gray, Lisa Clare, Hughes, Timothy Richard and Van Den Berg, Carmen Wilma 2010. Binding of human antigen R (HuR) to an AU-rich element (ARE) in the 3' untranslated region (3' UTR) reduces the expression of decay accelerating factor (DAF). Molecular Immunology 47 (16) , pp. 2545-2551. 10.1016/j.molimm.2010.07.002

Copland, D. A., Hussain, K., Baalasubramanian, Sivasankar, Hughes, Timothy Richard, Morgan, Bryan Paul, Xu, H., Dick, A. D. and Nicholson, L. B. 2010. Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis. Clinical and Experimental Immunology 159 (3) , pp. 303-314. 10.1111/j.1365-2249.2009.04070.x

Hughes, Timothy Richard, Ross, Kirsty S., Cowan, Graeme J. M., Baalasubramanian, Sivasank, Harris, Claire Louise, Mitchell, Timothy J. and Morgan, Bryan Paul 2009. Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Molecular Immunology 46 (7) , pp. 1561-1567. 10.1016/j.molimm.2009.01.003

Ruseva, Marieta Milkova, Hughes, Timothy Richard, Donev, Rossen Mintchev, Baalasubramanian, Sivasankar, Pickering, Matthew C., Wu, Xiaobo, Harris, Claire Louise and Morgan, Bryan Paul 2009. Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. Molecular Immunology 46 (5) , pp. 803-811. 10.1016/j.molimm.2008.09.003

Donev, Rossen Mintchev, Gray, Lisa Clare, Baalasubramanian, Sivasankar, Hughes, Timothy Richard, Van Den Berg, Carmen Wilma and Morgan, Bryan Paul 2008. Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma [RETRACTED]. Cancer Research 68 (14) , pp. 5979-5987. 10.1158/0008-5472.CAN-07-6828

Sivasankar, Baalasubramanian, Donev, Rossen Mintchev, Longhi, M. Paula, Hughes, Timothy Richard, Davies, Ruth, Cole, Duncan Sean, Morgan, Bryan Paul and Marchbank, Kevin J. 2007. CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Molecular Immunology 44 (11) , pp. 2978-2987. 10.1016/j.molimm.2006.12.025

Donev, Rossen Mintchev, Cole, Duncan Sean, Sivanaskar, Baalasubramanian, Hughes, Timothy Richard and Morgan, B. Paul 2006. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59 [RETRACTED]. Cancer Research 66 (4) , pp. 2451-8. 10.1158/0008-5472.CAN-05-3191

Irvine, Scott A., Martin, John, Hughes, Timothy Richard and Ramji, Dipak Purshottam 2006. Lipoprotein lipase is expressed by glomerular mesangial cells. The International Journal of Biochemistry & Cell Biology 38 (1) , pp. 12-16. 10.1016/j.biocel.2005.07.008

Mead, James R., Hughes, Timothy Richard, Irvine, Scott A., Singh, Nishi Nihar and Ramji, Dipak Purshottam 2003. Interferon-γ stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2: A Potentially novel pathway for interferon-γ-mediated inhibition of gene transcription. Journal of Biological Chemistry , pp. 17741-17751. 10.1074/jbc.M301602200

Hughes, Timothy Richard, Tengku-Muhammad, T. S., Irvine, S. A. and Ramji, Dipak Purshottam 2002. A novel role of Sp1 and Sp3 in the interferon- -mediated suppression of macrophage lipoprotein lipase gene transcription. Journal of Biological Chemistry 277 (13) , pp. 11097-11106. 10.1074/jbc.M106774200

Kockar, Feray Tura, Foka, Pelagia, Hughes, Timothy Richard, Kousteni, Stavroula and Ramji, Dipak Purshottam 2001. Analysis of the Xenopus laevis CCAAT-enhancer binding protein α gene promoter demonstrates species-specific differences in the mechanisms for both auto-activation and regulation by Sp1. Nucleic Acids Research 29 (2) , pp. 362-372. 10.1093/nar/29.2.362

Granger, Rachel L., Hughes, Timothy Richard and Ramji, Dipak Purshottam 2000. Gene, stimulus and cell-type specific regulation of activator protein-1 in mesangial cells by lipopolysaccharide and cytokines. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1492 (1) , pp. 100-107. 10.1016/S0167-4781(00)00089-0

Granger, Rachel L, Hughes, Timothy Richard and Ramji, Dipak Purshottam 2000. Stimulus- and cell-type-specific regulation of CCAAT-enhancer binding protein isoforms in glomerular mesangial cells by lipopolysaccharide and cytokines. Biochimica et Biophysica Acta - Molecular Basis of Disease 1501 (2-3) , pp. 171-179. 10.1016/S0925-4439(00)00016-8

This list was generated on Mon Sep 26 04:22:09 2022 BST.