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An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients

Wainwright, Shane Daniel, Bondeson, Jan and Hughes, Clare Elizabeth 2006. An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients. Matrix Biology 25 (5) , pp. 317-320. 10.1016/j.matbio.2006.03.006

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The major proteoglycan of articular cartilage aggrecan is a substrate for ADAMTS4. RT-PCR analysis of human osteoarthritic (OA) synovial co-cultures using oligonucleotide primers designed to amplify across the exon 8/9 junction of human ADAMTS4 resulted in the amplification of two products, the expected product and a smaller product missing 161 bp from the 5′ end of exon 9, the result of alternative splicing in which exon 8 joins to a cryptic 3′ splice site within exon 9. The protein produced would be identical to human ADAMTS4 up to Arg696, and would have a new C-terminal domain with no commonality with the ADAMTS4 spacer domain. Changes in the C-terminal domain of ADAMTS4 may alter its substrate specificity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords: ADAMTS4; Synovium; Alternative splice; Osteoarthritis
Publisher: Elsevier
ISSN: 0945-053X
Last Modified: 15 Dec 2017 08:35

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