Galperin, Moran, Farenc, Carine, Mukhopadhyay, Madhura, Jayasinghe, Dhilshan, Decroos, Amandine, Benati, Daniela, Tan, Li Lynn, Ciacchi, Lisa, Reid, Hugh H., Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Chakrabarti, Lisa A. and Gras, Stephanie 2018. CD4+ T cell–mediated HLA class II cross-restriction in HIV controllers. Science Immunology 3 (24) , eaat0687. 10.1126/sciimmunol.aat0687 |
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Abstract
Rare individuals, termed HIV controllers, spontaneously control HIV infection by mounting efficient T cell responses against the virus. Protective CD4+ T cell responses from HIV controllers involve high-affinity public T cell receptors (TCRs) recognizing an immunodominant capsid epitope (Gag293) presented by a remarkably broad array of human leukocyte antigen (HLA) class II molecules. Here, we determine the structures of a prototypical public TCR bound to HLA-DR1, HLA-DR11, and HLA-DR15 molecules presenting the Gag293 epitope. TCR recognition was driven by contacts with the Gag293 epitope, a feature that underpinned the extensive HLA cross-restriction. These high-affinity TCRs promoted mature immunological synapse formation and cytotoxic capacity in both CD4+ and CD8+ T cells. The public TCRs suppressed HIV replication in multiple genetic backgrounds ex vivo, emphasizing the functional advantage conferred by broad HLA class II cross-restriction.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | American Association for the Advancement of Science |
ISSN: | 2470-9468 |
Date of First Compliant Deposit: | 30 July 2018 |
Date of Acceptance: | 18 April 2018 |
Last Modified: | 07 Nov 2023 04:57 |
URI: | https://orca.cardiff.ac.uk/id/eprint/112932 |
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