Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

Edwards, Sarah C., Sutton, Caroline E., Ladell, Kristin, Grant, Emma J., McLaren, James E., Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L., Lalor, Stephen J., Ribot, Julie C., Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A., Thomas, Paul G., McLoughlin, Rachel M. and Mills, Kingston H.G. 2020. A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans. Journal of Experimental Medicine 217 (5) , e20190834. 10.1084/jem.20190834

PDF - Published Version
Available under License Creative Commons Attribution Non-commercial Share Alike.

Download (13MB) | Preview


T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to 10% of TCRδ+ cells in lymphoid organs. They expressed high levels of IL-1R1 and IL-23R and secreted IFN-γ, IL-17, and GM-CSF in response to canonically restricted peptide antigens or stimulation with IL-1β and IL-23. Hybrid αβ-γδ T cells were transcriptomically distinct from conventional γδ T cells and displayed a hyperinflammatory phenotype enriched for chemokine receptors and homing molecules that facilitate migration to sites of inflammation. These proinflammatory T cells promoted bacterial clearance after infection with Staphylococcus aureus and, by licensing encephalitogenic Th17 cells, played a key role in the development of autoimmune disease in the central nervous system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Rockefeller University Press
ISSN: 0022-1007
Date of First Compliant Deposit: 12 March 2020
Date of Acceptance: 17 January 2020
Last Modified: 20 Jan 2021 11:30

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics