An efficient one-pot multicomponent approach to 5-amino-7-aryl-8-nitrothiazolo[3,2-a]pyridines

Altug, C., Burnett, Alan Kenneth, Caner, E., Dürüst, Y., Elliott, Mark Christopher ORCID: https://orcid.org/0000-0003-0132-0818, Glanville, Roger P. J., Guy, Carol and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2011. An efficient one-pot multicomponent approach to 5-amino-7-aryl-8-nitrothiazolo[3,2-a]pyridines. Tetrahedron 67 (49) , pp. 9522-9528. 10.1016/j.tet.2011.10.005

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Abstract

A series of thiazolo[3,2-a]pyridines have been prepared using a multicomponent reaction between aromatic aldehydes, 2-nitromethylenethiazolidine and nitriles containing an active methylene group (malononitrile, ethyl 2-cyanoacetate and 2-phenylsulfonylacetonitrile) in the presence of Et3N under mild conditions with high yields. One of the compounds shows promising anticancer activity across a range of cancer cell lines.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry Schools > Medicine Schools > Pharmacy
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Multicomponent reactions; Heterocycles; Pyridine; Thiazoline; Knoevenagel reaction; Nitrile
Publisher:	Elsevier
ISSN:	0040-4020
Last Modified:	18 Oct 2022 13:23
URI:	https://orca.cardiff.ac.uk/id/eprint/13719

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