Altug, C., Burnett, Alan Kenneth, Caner, E., Dürüst, Y., Elliott, Mark Christopher ORCID: https://orcid.org/0000-0003-0132-0818, Glanville, Roger P. J., Guy, Carol and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2011. An efficient one-pot multicomponent approach to 5-amino-7-aryl-8-nitrothiazolo[3,2-a]pyridines. Tetrahedron 67 (49) , pp. 9522-9528. 10.1016/j.tet.2011.10.005 |
Official URL: http://www.sciencedirect.com/science/journal/00404...
Abstract
A series of thiazolo[3,2-a]pyridines have been prepared using a multicomponent reaction between aromatic aldehydes, 2-nitromethylenethiazolidine and nitriles containing an active methylene group (malononitrile, ethyl 2-cyanoacetate and 2-phenylsulfonylacetonitrile) in the presence of Et3N under mild conditions with high yields. One of the compounds shows promising anticancer activity across a range of cancer cell lines.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Medicine Pharmacy |
Subjects: | Q Science > QD Chemistry |
Uncontrolled Keywords: | Multicomponent reactions; Heterocycles; Pyridine; Thiazoline; Knoevenagel reaction; Nitrile |
Publisher: | Elsevier |
ISSN: | 0040-4020 |
Last Modified: | 18 Oct 2022 13:23 |
URI: | https://orca.cardiff.ac.uk/id/eprint/13719 |
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