Innate immunity in latent autoimmune diabetes in adults (LADA)

Huang, Juan, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Wen, Li and Zhou, Zhiguang 2022. Innate immunity in latent autoimmune diabetes in adults (LADA). Diabetes/Metabolism Research and Reviews 38 (1) , e3480. 10.1002/dmrr.3480

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Abstract

Latent autoimmune diabetes in adults (LADA) is an autoimmune disease that shares some genetic, immunological, and clinical features with both type 1 diabetes and type 2 diabetes. Immune cells including CD4+ T cells, CD8+ T cells, B cells, macrophages, and dendritic cells (DCs) have been detected in the pancreas of patients with LADA and a rat model of LADA. Therefore, similar to type 1 diabetes, the pathogenesis of LADA may be caused by interactions between islet β-cells and innate and adaptive immune cells. However, the role of the immunity in the initiation and progression of LADA remains largely unknown. In this review, we have summarized the potential roles of innate immunity and immune-modulators in LADA development. Furthermore, we have examined the evidence and discussed potential innate immunological reasons for the slower development of LADA compared with type 1 diabetes. More in-depth mechanistic studies are needed to fully elucidate the roles of innate immune-associated genes, molecules, and cells in their contributions to LADA pathogenesis. Undertaking these studies will greatly enhance the development of new strategies and optimization of current strategies for the diagnosis and treatment of the disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	John Wiley and Sons
ISSN:	1520-7552
Date of First Compliant Deposit:	17 June 2021
Date of Acceptance:	11 May 2021
Last Modified:	02 Dec 2024 17:45
URI:	https://orca.cardiff.ac.uk/id/eprint/141949

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