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Number of items: 38.

Jenkins, Benjamin J., Jenkins, Yasmin R., Ponce-Garcia, Fernando M., Moscrop, Chloe, Perry, Iain A., Hitchings, Matthew D., Uribe, Alejandro H., Bernuzzi, Federico, Eastham, Simon, Cronin, James G., Berisha, Ardena, Howell, Alexandra, Davies, Joanne, Blagih, Julianna, Williams, Marta, Marsden, Morgan, Veale, Douglas J., Davies, Luke C., Niphakis, Micah, Finlay, David K., Sinclair, Linda V., Cravatt, Benjamin F., Hogan, Andrew E., Nathan, James A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Fearon, Ursula, Sumpton, David, Vande Voorde, Johan, Vale, Goncalo Dias do, McDonald, Jeffrey G., Jones, Gareth W., Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Vincent, Emma E. and Jones, Nicholas 2025. Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function. Nature Communications 16 (1) , 9484. 10.1038/s41467-025-65417-4
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Zhang, Luyao, Xing, Yanpeng, Wang, Pai, Gu, Jianlei, Peng, Jian, Huang, Juan, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Youjia, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2025. Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice. Frontiers in Endocrinology 16 , 1630979. 10.3389/fendo.2025.1630979
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269 and Hanna, Stephanie J. 2025. Mini review: Interleukin-32 as a key mediator of type 1 diabetes pathogenesis. Frontiers in Immunology 16 , 1641698. 10.3389/fimmu.2025.1641698
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Jenkins, Benjamin, Jenkins, Yasmin, Ponce-Garcia, Fernando, Moscrop, Chloe, Perry, Iain, Hitchings, Matthew, Uribe, Alejandro, Bernuzzi, Federico, Eastham, Simon, Cronin, James, Berisha, Ardena, Howell, Alexandra, Davies, Joanne, Blagih, Julianna, Veale, Douglas, Davies, Luke, Niphakis, Micah, Finlay, David, Sinclair, Linda, Cravatt, Benjamin, Hogan, Andrew, Nathan, James, Fearon, Ursula, Sumpton, David, Vande Voorde, Johan, Dias do Vale, Goncalo, McDonald, Jeffrey, Jones, Gareth, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Vincent, Emma and Jones, Nicholas 2025. ABHD11 inhibition drives sterol metabolism to modulate T cell effector function 2 and alleviate autoimmunity. [Online]. bioRxiv: openRxiv. Available at: https://doi.org/10.1101/2025.03.19.643996
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Haq, N., Toczyska, K. W., Wilson, M. E., Jacobs, M., Zhao, Min, Lei, Y., Shen, Z., Pearson, J. A. ORCID: https://orcid.org/0000-0002-2867-2269, Persaud, S. J., Pullen, T. J. and Bewick, G. A. 2024. Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology. Cell Death Discovery 10 , 480. 10.1038/s41420-024-02234-6
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Wang, Pai, Yang, Xin, Zhang, Luyao, Sha, Sha, Huang, Juan, Peng, Jian, Gu, Jianlei, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Youjia, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Wang, Quan and Wen, Li 2024. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 15 (1) , 4232. 10.1038/s41467-024-48611-8
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Youjia, Peng, Jian, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2024. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. Frontiers in Immunology 15 , 1333967. 10.3389/fimmu.2024.1333967
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Huang, Juan, Yu, Xiaoqing, Tai, Ningwen, Hu, Youjia, Sha, Sha, Flavell, Richard A., Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2023. NLRP6 deficiency expands a novel CD103 + B cell population that confers immune tolerance in NOD mice. Frontiers in Immunology 14 , 1147925. 10.3389/fimmu.2023.1147925
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Boldison, Joanne, Hopkinson, Jessica R., Davies, Joanne, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Leete, Pia, Richardson, Sarah, Morgan, Noel G. and Wong, F. Susan 2022. Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes. Diabetologia 66 (3) , pp. 551-566. 10.1007/s00125-022-05839-7
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Ding, Heyuan, Hu, Changyun, Peng, Jian, Galuppo, Brittany, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Caprio, Sonia, Santoro, Nicola and Wen, Li 2022. IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans. Diabetologia 65 (8) , pp. 1398-1411. 10.1007/s00125-022-05711-8
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Chan, Karl, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269 2022. Circadian rhythms and pancreas physiology: A review. Frontiers in Endocrinology 13 , 920261. 10.3389/fendo.2022.920261
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, McKinney, Eoin F. and Walker, Lucy S. K. 2022. 100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes. Immunotherapy Advances 10.1093/immadv/ltab024
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Huang, Juan, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Wen, Li and Zhou, Zhiguang 2022. Innate immunity in latent autoimmune diabetes in adults (LADA). Diabetes/Metabolism Research and Reviews 38 (1) , e3480. 10.1002/dmrr.3480
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Voisey, Alexander Christopher ORCID: https://orcid.org/0000-0001-6906-9397, Boest Bjerg, Kathrine, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. Circadian rhythm modulation of microbes during health and infection. Frontiers in Microbiology 12 , 721004. 10.3389/fmicb.2021.721004
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Huang, Juan, Tan, Qiyuan, Tai, Ningwen, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Li, Yangyang, Chao, Chen, Zhang, Lucy, Peng, Jian, Xing, Yanpeng, Zhang, Luyao, Hu, Youjia, Zhou, Zhiguang, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. IL-10 deficiency accelerates type 1 diabetes development via modulation of innate and adaptive immune cells and gut microbiota in BDC2.5 NOD mice. Frontiers in Immunology 12 , 702955. 10.3389/fimmu.2021.702955
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. Inflammasomes and type 1 diabetes. Frontiers in Immunology 12 , 686956. 10.3389/fimmu.2021.686956
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Thayer, Terri C., Davies, Joanne, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Hanna, Stephanie J., Wen, Li and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70 (2) , pp. 529-537. 10.2337/db19-1050

Sha, Sha, Pearson, James A ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Hu, Youjia, Huang, Juan, Xing, Yanpeng, Zhang, Luyao, Zhu, Ying, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Chen, Li and Wen, Li 2021. TLR9-deficiency in B cells promotes immune tolerance via IL-10 in a type 1 diabetes mouse model. Diabetes 70 (2) , pp. 504-515. 10.2337/db20-0373
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Huang, Juan, Peng, Jian, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Efthimiou, Georgios, Hu, Youjia, Tai, Ningwen, Xing, Yanpeng, Zhang, Luyao, Gu, Jianlei, Jiang, Jianping, Zhao, Hongyu, Zhou, Zhiguang, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology 18 , pp. 328-338. 10.1038/s41423-020-00590-8
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2020. Crosstalk between circadian rhythms and the microbiota. Immunology 161 (4) , pp. 278-290. 10.1111/imm.13278
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Li, Yangyang, Majewska-Szczepanik, Monika, Guo, Junhua, Zhang, Li, Liu, Yu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2020. Insulin-reactive T cells convert diabetogenic insulin-reactive VH125 B cells into tolerogenic cells by reducing germinal center T:B cell Interactions in NOD mice. Frontiers in Immunology 11 , 585886. 10.3389/fimmu.2020.585886
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Huang, Juan, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Hu, Youjia, Sha, Sha, Xing, Yanpeng, Huang, Gan, Li, Xia, Hu, Fang, Xie, Zhiguo, Xiao, Yang, Luo, Shuoming, Chao, Chen, Wong, Florence S. ORCID: https://orcid.org/0000-0002-2812-8845, Zhou, Zhiguang and Wen, Li 2020. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight 5 (10) , e135718. 10.1172/jci.insight.135718
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Tai, Ningwen, Ekanayake-Alper, Dilrukshi K., Peng, Jian, Hu, Youjia, Hager, Karl, Compton, Susan, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Smith, Peter C. and Wen, Li 2019. Norovirus changes susceptibility to type 1 diabetes by altering intestinal microbiota and immune cell functions. Frontiers in Immunology 10 , 2654. 10.3389/fimmu.2019.02654
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Kakabadse, Dimitri, Davies, Joanne, Peng, Jian, Warden-Smith, Jeremy, Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Lewis, Mark, Camargo da Rosa, Larissa, Wen, Li and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2019. Altered gut microbiota activate and expand insulin B15-23-Reactive CD8+ T-Cells. Diabetes 68 (5) , pp. 1002-1013. 10.2337/db18-0487
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Liu, Mengju, Peng, Jian, Tai, Ningwen, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Changyun, Guo, Junhua, Hou, Lin, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2018. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 61 (11) , pp. 2333-2343. 10.1007/s00125-018-4705-0
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Gülden, Elke, Chao, Chen, Tai, Ningwen, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Majewska-Szczepanik, Monika, Zhou, Zhiguang, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2018. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells. Journal of Autoimmunity 93 , pp. 57-65. 10.1016/j.jaut.2018.06.003
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Majewska-Szczepanik, Monika, Kowalczyk, Paulina, Biała, Dominika, Marcińska, Katarzyna, Strzępa, Anna, Woźniak, Dorota, Sura, Piotr, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Wen, Li and Szczepanik, Marian 2018. Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression. Pharmacological Reports 70 (4) , pp. 796-803. 10.1016/j.pharep.2018.02.015

Tan, Qiyuan, Tai, Ningwen, Li, Yangyang, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Pennetti, Sean, Zhou, Zhiguang, Wong, Florence ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2018. Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 3 (1) , 95882. 10.1172/jci.insight.95882
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Li, Y. Y., Pearson, J. A. ORCID: https://orcid.org/0000-0002-2867-2269, Chao, C., Peng, J., Zhang, X., Zhou, Z., Liu, Y., Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, L. 2017. Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota. Journal of Autoimmunity 82 , pp. 85-95. 10.1016/j.jaut.2017.05.007
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Thayer, Terri C., Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, De Leenheer, Evy, Hanna, Stephanie J., Boldison, Joanne, Davies, Joanne ORCID: https://orcid.org/0000-0002-7369-6032, Tsui, Adrian, Ahmed, Sartaj, Easton, Peter, Siew, Lai Khai, Wen, Li and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65 (11) , pp. 3429-3439. 10.2337/db15-1649
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Gras, Stephanie, Van den berg, Hugo, Lissina, Anya, Llewellyn-Lacey, Sian, Willis, Mark ORCID: https://orcid.org/0000-0003-3024-6063, Dockree, Tamsin, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Ekeruche-Makinde, Julia, Gostick, Emma, Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909, Burrows, Scott, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Peakman, Mark, Skowera, Ania and Wooldridge, Linda 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6 , 35332. 10.1038/srep35332
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Thayer, Terri C., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly, Morgan, Peter ORCID: https://orcid.org/0000-0002-8555-3493, Wen, Li, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65 (6) , pp. 1679-1689. 10.2337/db15-1498
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2016. The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. Journal of Autoimmunity 66 , pp. 76-88. 10.1016/j.jaut.2015.08.019

Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269 and Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 2015. Identification of islet antigen-specific CD8 T cells using MHCI-peptide tetramer reagents in the non obese diabetic (NOD) mouse model of type 1 diabetes. Gillespie, Kathleen M., ed. Type-1 Diabetes, Vol. 1433. Methods in Molecular Biology, Springer, pp. 119-125. (10.1007/7651_2015_295)

Ye, Jody, Long, Anna E., Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Taylor, Hazel, Bingley, Polly J., Williams, Alistair J. K. and Gillespie, Kathleen M. 2015. Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes. Diabetologia 58 (10) , pp. 2284-2287. 10.1007/s00125-015-3702-9

Hu, Changyun, Ding, Heyuan, Li, Yangyang, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Zhang, Xiaojun, Flavell, Richard A., Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2015. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings of the National Academy of Sciences 112 (36) , pp. 11318-11323. 10.1073/pnas.1513509112

Motozono, Chihiro, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, De Leenheer, Evy, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Trimby, Andrew, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290 (31) , pp. 18924-18933. 10.1074/jbc.M114.622522
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Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269 2014. Analysis of the repertoire of insulin-reactive CD8+ T cells. PhD Thesis, Cardiff University.
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