Boldison, Joanne, Da Rosa, Larissa Camargo and Wong, F. Susan ![]() |
Abstract
Type 1 diabetes is an organ-specific autoimmune disease characterized by immune-mediated beta cell destruction in pancreatic islets, which results in deficient insulin production. B cells have a dual role in type 1 diabetes pathogenesis. A pathogenic role for B cells has been widely described and is supported by the observation of a delay in the loss of C-peptide following B-cell depletion by Rituximab, in the first year after diagnosis. However, it is now clear that B cells, under certain conditions, can delay and prevent the onset of type 1 diabetes as demonstrated in mouse models. In this chapter, we describe the methods required to study the phenotype and function of regulatory B cells in the context of diabetes.
Item Type: | Book Section |
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Date Type: | Published Online |
Status: | Published |
Schools: | Medicine |
Publisher: | Humana Press |
ISBN: | 9781071612378 |
ISSN: | 1064-3745 |
Last Modified: | 10 Nov 2022 09:41 |
URI: | https://orca.cardiff.ac.uk/id/eprint/143983 |
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