Regulatory B cells in type 1 diabetes

Boldison, Joanne, Da Rosa, Larissa Camargo and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2021. Regulatory B cells in type 1 diabetes. Mion, Francesca and Tonon, Silvia, eds. Regulatory B Cells, Vol. 2270. Methods in Molecular Biology, New York, US: Humana Press, pp. 419-435. (10.1007/978-1-0716-1237-8_22)

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Abstract

Type 1 diabetes is an organ-specific autoimmune disease characterized by immune-mediated beta cell destruction in pancreatic islets, which results in deficient insulin production. B cells have a dual role in type 1 diabetes pathogenesis. A pathogenic role for B cells has been widely described and is supported by the observation of a delay in the loss of C-peptide following B-cell depletion by Rituximab, in the first year after diagnosis. However, it is now clear that B cells, under certain conditions, can delay and prevent the onset of type 1 diabetes as demonstrated in mouse models. In this chapter, we describe the methods required to study the phenotype and function of regulatory B cells in the context of diabetes.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	Humana Press
ISBN:	9781071612378
ISSN:	1064-3745
Last Modified:	10 Nov 2022 09:41
URI:	https://orca.cardiff.ac.uk/id/eprint/143983

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