Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery

Zappala, Stefano, Bennion, Nicholas J., Potts, Matthew R., Wu, Jing ORCID: https://orcid.org/0000-0001-5123-9861, Kusmia, Slawomir, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Evans, Sam L. ORCID: https://orcid.org/0000-0003-3664-2569 and Marshall, David ORCID: https://orcid.org/0000-0003-2789-1395 2021. Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery. Scientific Reports 11 (1) , 17684. 10.1038/s41598-021-97150-5

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Abstract

Positional brain shift (PBS), the sagging of the brain under the effect of gravity, is comparable in magnitude to the margin of error for the success of stereotactic interventions (∼ 1 mm). This non-uniform shift due to slight differences in head orientation can lead to a significant discrepancy between the planned and the actual location of surgical targets. Accurate in-vivo measurements of this complex deformation are critical for the design and validation of an appropriate compensation to integrate into neuronavigational systems. PBS arising from prone-to-supine change of head orientation was measured with magnetic resonance imaging on 11 young adults. The full-field displacement was extracted on a voxel-basis via digital volume correlation and analysed in a standard reference space. Results showed the need for target-specific correction of surgical targets, as a significant displacement ranging from 0.52 to 0.77 mm was measured at surgically relevant structures. Strain analysis further revealed local variability in compressibility: anterior regions showed expansion (both volume and shape change), whereas posterior regions showed small compression, mostly dominated by shape change. Finally, analysis of correlation demonstrated the potential for further patient- and intervention-specific adjustments, as intra-cranial breadth and head tilt correlated with PBS reaching statistical significance.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering Psychology Computer Science & Informatics Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information:	Tis article is licensed under a Creative Commons Attribution 4.0 International License, http://creativecommons.org/licenses/by/4.0/.
Publisher:	Nature Research
ISSN:	2045-2322
Date of First Compliant Deposit:	13 September 2021
Date of Acceptance:	13 August 2021
Last Modified:	28 Jan 2024 14:35
URI:	https://orca.cardiff.ac.uk/id/eprint/144055

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