Survey of in vitro model systems for Investigation of key cellular processes associated with atherosclerosis

Ramji, Dipak P. ORCID: https://orcid.org/0000-0002-6419-5578, Ismail, Alaa, Chen, Jing, Alradi, Fahad and Al Alawi, Sulaiman 2022. Survey of in vitro model systems for Investigation of key cellular processes associated with atherosclerosis. Ramji, Dipak P., ed. Atherosclerosis: Methods and Protocols, Vol. 2419. New York, NY: Springer, pp. 39-56. (10.1007/978-1-0716-1924-7_3)

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Abstract

Atherosclerosis progression is associated with a complex array of cellular processes in the arterial wall, including endothelial cell activation/dysfunction, chemokine-driven recruitment of immune cells, differentiation of monocytes to macrophages and their subsequent transformation into lipid laden foam cells, activation of inflammasome and pro-inflammatory signaling, and migration of smooth muscle cells from the media to the intima. The use of in vitro model systems has considerably advanced our understanding of these atherosclerosis-associated processes and they are also often used in drug discovery and other screening platforms. This chapter will describe key in vitro model systems employed frequently in atherosclerosis research.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Springer
ISBN:	9781071619230
ISSN:	1064-3745
Last Modified:	10 Jul 2024 16:00
URI:	https://orca.cardiff.ac.uk/id/eprint/148038

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