Ramji, Dipak P.  ORCID: https://orcid.org/0000-0002-6419-5578, Ismail, Alaa, Chen, Jing, Alradi, Fahad and Al Alawi, Sulaiman
2022.
Survey of in vitro model systems for Investigation of key cellular processes associated with atherosclerosis.
Ramji, Dipak P., ed.
Atherosclerosis: Methods and Protocols,
Vol. 2419.
New York, NY:
Springer,
pp. 39-56.
(10.1007/978-1-0716-1924-7_3)
|
Abstract
Atherosclerosis progression is associated with a complex array of cellular processes in the arterial wall, including endothelial cell activation/dysfunction, chemokine-driven recruitment of immune cells, differentiation of monocytes to macrophages and their subsequent transformation into lipid laden foam cells, activation of inflammasome and pro-inflammatory signaling, and migration of smooth muscle cells from the media to the intima. The use of in vitro model systems has considerably advanced our understanding of these atherosclerosis-associated processes and they are also often used in drug discovery and other screening platforms. This chapter will describe key in vitro model systems employed frequently in atherosclerosis research.
| Item Type: | Book Section |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences |
| Publisher: | Springer |
| ISBN: | 9781071619230 |
| ISSN: | 1064-3745 |
| Last Modified: | 10 Jul 2024 16:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/148038 |
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