The role of glycoconjugates as receptors for insecticidal proteins

Best, Hannah L., Williamson, Lainey J., Heath, Emily A., Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064, Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611 and Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X 2023. The role of glycoconjugates as receptors for insecticidal proteins. FEMS Microbiology Reviews 47 (4) 10.1093/femsre/fuad026

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Abstract

Bacillus thuringiensis (Bt) proteins are an environmentally safe and effective alternative to chemical pesticides and have been used as biopesticides, with great commercial success, for over 50 years. Global agricultural production is predicted to require a 70% increase until 2050 to provide for an increasing population. In addition to agriculture, Bt proteins are utilised to control human vectors of disease – namely mosquitoes – which account for >700,000 deaths annually. The evolution of resistance to Bt pesticial toxins threatens the progression of sustainable agriculture. Whilst Bt protein toxins are heavily utilised, the exact mechanisms behind receptor binding and toxicity are unknown. It is critical to gain a better understanding of these mechanisms in order to engineer novel toxin variants and to predict, and prevent, future resistance evolution. This review focuses on the role of carbohydrate binding in the toxicity of the most utilised group of Bt pesticidal proteins – three domain Cry (3D-Cry) toxins.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Pharmacy
Publisher:	Oxford University Press
ISSN:	0168-6445
Date of First Compliant Deposit:	1 June 2023
Date of Acceptance:	10 June 2023
Last Modified:	06 Mar 2024 02:08
URI:	https://orca.cardiff.ac.uk/id/eprint/160113

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