Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

Bug, Gesine, Schwarz, Kerstin, Schoch, Claudia, Kampfmann, Manuela, Henschler, Reinhard, Hoelzer, Dieter, Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330 and Ruthardt, Martin ORCID: https://orcid.org/0000-0003-1021-3811 2007. Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia. Haematologica 92 (4) 10.3324/haematol.10758

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Abstract

Histone deacetylase inhibitor valproic acid (VPA) was recently shown to enhance proliferation and self-renewal of normal hematopoietic stem cells, raising the possibility that VPA may also support growth of leukemic progenitor cells (LPC). Here, VPA maintains a significantly higher proportion of CD34+ LPC and colony forming units compared to control cultures in six AML samples, but selectively reduces leukemic cell numbers in another AML sample with expression of AML1/ETO. Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Ferrata Storti Foundation
ISSN:	0390-6078
Last Modified:	23 Feb 2024 16:00
URI:	https://orca.cardiff.ac.uk/id/eprint/166074

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