Bug, Gesine, Schwarz, Kerstin, Schoch, Claudia, Kampfmann, Manuela, Henschler, Reinhard, Hoelzer, Dieter, Ottmann, Oliver G. ![]() ![]() |
Official URL: https://doi.org/10.3324/haematol.10758
Abstract
Histone deacetylase inhibitor valproic acid (VPA) was recently shown to enhance proliferation and self-renewal of normal hematopoietic stem cells, raising the possibility that VPA may also support growth of leukemic progenitor cells (LPC). Here, VPA maintains a significantly higher proportion of CD34+ LPC and colony forming units compared to control cultures in six AML samples, but selectively reduces leukemic cell numbers in another AML sample with expression of AML1/ETO. Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Schools > Medicine |
Publisher: | Ferrata Storti Foundation |
ISSN: | 0390-6078 |
Last Modified: | 23 Feb 2024 16:00 |
URI: | https://orca.cardiff.ac.uk/id/eprint/166074 |
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