Nicholson, Robert Ian, McClelland, Richard Andrew, Gee, Julia Margaret Wendy  ORCID: https://orcid.org/0000-0001-6483-2015, Manning, D. L., Cannon, P., Robertson, J. F. R., Ellis, I. O. and Blamey, R. W.
1994.
Transforming growth factor-α and endocrine sensitivity in breast cancer.
Cancer Research
54
(7)
, pp. 1684-1689.
|
Abstract
The expression of transforming growth factor-α (TGF-α) has been evaluated in 51 breast cancers of known responsiveness to endocrine therapy using immunohistochemistry. High levels of TGF-α were observed in 65% of tumors and showed no relationship with tumor estrogen receptor or epidermal growth factor receptor status or Ki67 immunostaining. TGF-α levels did, however, relate to the endocrine sensitivity of the disease, with unresponsive tumors frequently showing high levels of TGF-α immunoreactivity. This relationship was observed in estrogen receptor-positive disease and was independent of the epidermal growth factor receptor status of the tumor. No quantitative association between TGF-α and Ki67 immunostaining was observed in any of the subcategories of tumors. These data infer a role for TGF-α in the development of endocrine insensitivity in estrogen receptor-positive breast cancer by mechanisms which appear independent of tumor growth fraction, as determined by Ki67 immunostaining.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Pharmacy Schools > Medicine |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology |
| Publisher: | American Association for Cancer Research |
| ISSN: | 0008-5472 |
| Last Modified: | 18 Oct 2022 14:19 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/17131 |
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