Transforming growth factor-α and endocrine sensitivity in breast cancer

Nicholson, Robert Ian, McClelland, Richard Andrew, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Manning, D. L., Cannon, P., Robertson, J. F. R., Ellis, I. O. and Blamey, R. W. 1994. Transforming growth factor-α and endocrine sensitivity in breast cancer. Cancer Research 54 (7) , pp. 1684-1689.

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Abstract

The expression of transforming growth factor-α (TGF-α) has been evaluated in 51 breast cancers of known responsiveness to endocrine therapy using immunohistochemistry. High levels of TGF-α were observed in 65% of tumors and showed no relationship with tumor estrogen receptor or epidermal growth factor receptor status or Ki67 immunostaining. TGF-α levels did, however, relate to the endocrine sensitivity of the disease, with unresponsive tumors frequently showing high levels of TGF-α immunoreactivity. This relationship was observed in estrogen receptor-positive disease and was independent of the epidermal growth factor receptor status of the tumor. No quantitative association between TGF-α and Ki67 immunostaining was observed in any of the subcategories of tumors. These data infer a role for TGF-α in the development of endocrine insensitivity in estrogen receptor-positive breast cancer by mechanisms which appear independent of tumor growth fraction, as determined by Ki67 immunostaining.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Publisher:	American Association for Cancer Research
ISSN:	0008-5472
Last Modified:	18 Oct 2022 14:19
URI:	https://orca.cardiff.ac.uk/id/eprint/17131

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