Modulation of oestrogen action by receptor gene inhibition

Madden, Tracie-Ann ORCID: https://orcid.org/0000-0001-7880-7873, Barrow, Denise, McClelland, Richard Andrew, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015 and Nicholson, Robert Ian 2000. Modulation of oestrogen action by receptor gene inhibition. European Journal of Cancer 36 (S4) , pp. 34-35. 10.1016/S0959-8049(00)00216-1

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Abstract

Selective oestrogen receptor downregulators (SERDs) are a class of highly effective steroidal antitumour agents that reduce cellular levels of the oestrogen receptor (ER). In this study, we compared the efficacy by which three novel molecular approaches: (1) antisense oligonucleotides; (2) antisense RNA; and (3) dominant negative mutants are able to act as SERDs. Using transient and, where appropriate, stable gene transfection experiments we found that constitutive overexpression of ER antisense RNA and a hormone-binding domain compromised dominant-negative ER mutant (DNER-1), were most effective at downregulating ER expression and/or activity in vitro.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy Schools > Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Breast cancer; Oestrogen receptor; Antisense; Dominant-negative; Gene inhibition
Publisher:	Elsevier
ISSN:	0014-2964
Last Modified:	18 Oct 2022 14:20
URI:	https://orca.cardiff.ac.uk/id/eprint/17173

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