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Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro.
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Hutcheson, Iain Robert, Goddard, Lindy, Barrow, Denise, McClelland, Richard Andrew, Francies, Hayley E., Knowlden, Janice Mary, Nicholson, Robert Ian and Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015
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Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1.
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2011.
Antihormone induced compensatory signalling in breast cancer: an adverse event in the development of endocrine resistance.
Hormone Molecular Biology and Clinical Investigation
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Knowlden, Janice Mary, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Barrow, Denise, Robertson, John F., Ellis, Ian O., Nicholson, Robert Ian and Hutcheson, Iain Robert
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erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines.
Breast Cancer Research
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Knowlden, Janice Mary, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Barrow, Denise, Robertson, J. F., Ellis, I. O., Nicholson, Robert Ian and Hutcheson, Iain Robert
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O-36 Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells [Abstract].
EJC Supplements
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Knowlden, Janice Mary, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Barrow, Denise, Robertson, J. F., Ellis, I. O., Nicholson, Robert Ian and Hutcheson, Iain Robert
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Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells [Abstract].
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Fulvestrant-induced expression of erbB3 and erbB4 sensitizes ER-positive breast cancer cells to heregulins [Abstract].
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The dark side of antihormonal action in breast cancer.
Hiscox, Stephen Edward, Gee, Julia Margaret Wendy and Nicholson, Robert Ian, eds.
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Knowlden, Janice Mary, Jones, Helen E., Barrow, Denise, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Nicholson, Robert Ian and Hutcheson, Iain Robert
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Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib ('Iressa') response and resistance.
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Hutcheson, Iain Robert, Knowlden, Janice Mary, Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Barrow, Denise, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Robertson, J. F., Ellis, I. O. and Nicholson, Robert Ian
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Heregulin beta 1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells.
Breast Cancer Research
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Jones, Helen E., Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Hutcheson, Iain Robert, Knowlden, Janice Mary, Barrow, Denise and Nicholson, Robert Ian
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Growth factor receptor interplay and resistance in cancer.
Endocrine-Related Cancer
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10.1677/erc.1.01275
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Hutcheson, Iain Robert, Knowlden, Janice Mary, Jones, Helen E., Burmi, R. S., McClelland, Richard Andrew, Barrow, Denise, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015 and Nicholson, Robert Ian
2006.
Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy.
Endocrine-Related Cancer
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10.1677/erc.1.01279
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Burmi, Rajpal Singh, McClelland, Richard Andrew, Barrow, Denise, Ellis, I. O., Robertson, J. F. R., Nicholson, Robert Ian and Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015
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Microarray studies reveal novel genes associated with endocrine resistance in breast cancer [Abstract].
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Jones, Helen E., Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Barrow, Denise, Tonge, D., Holloway, B. and Nicholson, Robert Ian
2006.
Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells.
British Journal of Cancer
95
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Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Morgan, Liam David ORCID: https://orcid.org/0000-0002-7571-6025, Green, Tim P., Barrow, Denise, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015 and Nicholson, Robert Ian
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Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.
Breast cancer research and treatment
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Britton, David James, Hutcheson, Iain Robert, Knowlden, Janice Mary, Barrow, Denise, Giles, Martin Gwyn, McClelland, Richard Andrew, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015 and Nicholson, Robert Ian
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Bidirectional cross talk between ER alpha and EGFR signalling pathways regulates tamoxifen-resistant growth.
Breast Cancer Research and Treatment
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Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Obermeier, Kathrin, Taylor, Kathryn Mary ORCID: https://orcid.org/0000-0002-9576-9490, Morgan, Liam David ORCID: https://orcid.org/0000-0002-7571-6025, Burmi, Rajpal Singh, Barrow, Denise and Nicholson, Robert Ian
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Tamoxifen-resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of [beta]-catenin phosphorylation.
International journal of cancer
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Jones, Helen E., Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Barrow, Denise, Holloway, B., Tonge, D. and Nicholson, Robert Ian
2006.
Maintenance of EGFR phosphorylation by the IGF-1R in the presence of gefitinib in lung cancer cells: Co-targeting the EGFR and IGF-1R maximises anti-tumour effects [Abstract].
Annals of Oncology
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Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor.
Endocrinology
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Pearton, Marc, Barrow, Denise, Gateley, C., Anstey, Alexander Vincent ORCID: https://orcid.org/0000-0002-6345-4144, Wilke, N., Morrissey, A., Allender, Christopher John, Brain, Keith Roger and Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924
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Hydrogels based on PLGA-PEG-PLGA triblock co-polymers as sustained release reservoirs for the delivery of pDNA to microneedle treated human skin [Abstract].
Journal of Pharmacy and Pharmacology
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Nicholson, Robert Ian, Hutcheson, Iain Robert, Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Knowlden, Janice Mary, Giles, Martin Gwyn, Barrow, Denise and Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015
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Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of anti-growth factor therapies to treat or delay endocrine resistance in breast cancer.
Endocrine-Related Cancer
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Jones, Helen E., Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Taylor, Kathryn Mary ORCID: https://orcid.org/0000-0002-9576-9490, Barrow, Denise, Williams, Hywel David, Rubini, M. and Nicholson, Robert Ian
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Development of strategies for the use of anti-growth factor treatments.
Endocrine-Related Cancer
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Nicholson, Robert Ian, Hutcheson, Iain Robert, Britton, David James, Knowlden, Janice Mary, Jones, Helen E., Harper, Maureen Elaine, Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Barrow, Denise and Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015
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Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies.
The Journal of Steroid Biochemistry and Molecular Biology
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Jones, Helen E., Goddard, Lindy, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Rubini, M., Barrow, Denise, Knowlden, Janice Mary, Williams, Sophie E., Wakeling, A. E. and Nicholson, Robert Ian
2004.
Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells.
Endocrine-Related Cancer
11
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10.1677/erc.1.00799
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Jordan, Nicola Jane, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Barrow, Denise, Wakeling, A. E. and Nicholson, Robert Ian
2004.
Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells.
Breast Cancer Research and Treatment
87
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10.1023/B:BREA.0000041623.21338.47
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Coulman, S. A., Allender, Christopher John, Barrow, Denise, Gateley, C., Anstey, Alexander Vincent ORCID: https://orcid.org/0000-0002-6345-4144 and Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924
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Microneedle facilitated cutaneous delivery of a non-viral gene complex to the viable epidermis [Abstract].
Journal of Pharmacy and Pharmacology
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Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Morgan, Liam David ORCID: https://orcid.org/0000-0002-7571-6025, Barrow, Denise, Dutkowski, Carol Mary, Wakeling, Alan and Nicholson, Robert Ian
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Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839).
Clinical & Experimental Metastasis
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Treatment of tamoxifen-resistant MCF-7 breast cancer cells with either gefitinib ('Iressa') or trastuzumab (Herceptin((R))) generates cross-resistant phenotypes [Abstract].
Breast Cancer Research and Treatment
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Nicholson, Robert, Hutcheson, Iain Robert, Knowlden, Janice Mary, Jones, Helen E., Harper, Maureen Elaine, Jordan, Nicola Jane, Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Barrow, Denise and Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015
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Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination.
Clinical Cancer Research
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Nicholson, Robert, Hutcheson, Iain Robert, Knowlden, Janice Mary, Britton, David James, Harper, Maureen Elaine, Jordan, Nicola Jane, Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Barrow, Denise and Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015
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Chapter 16: beyond antihormones in the targeted therapy of breast cancer.
Ingle, James N. and Dowsett, Mitchell, eds.
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Hutcheson, Iain Robert, Knowlden, Janice Mary, Madden, Tracie-Ann ORCID: https://orcid.org/0000-0001-7880-7873, Barrow, Denise, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Wakeling, A. E. and Nicholson, Robert Ian
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Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells.
Breast Cancer Research and Treatment
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Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells.
Endocrinology
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Heregulin-induced AKT activation promotes growth of gefitinib ('Iressa', ZD1839)-treated, tamoxifen-resistant breast cancer cells [Abstract].
Breast Cancer Research and Treatment
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Britton, D. J., Hutcheson, Iain Robert, Barrow, Denise, McClelland, Richard Andrew, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015 and Nicholson, Robert Ian
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Oestrogen receptor phosphorylation in hormone sensitive and anti-hormone resistant breast cancer cells [Abstract].
Breast Cancer Research and Treatment
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The biology of antihormone failure in breast cancer.
Breast Cancer Research and Treatment
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Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer.
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ZD1839 (Iressa) improves the antitumor activity of tamoxifen (Nolvadex) in antihormone-responsive breast cancer cells [Abstract].
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Modulation of oestrogen action by receptor gene inhibition.
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Comparative studies of the mitogenic effects of epidermal growth factor and transforming growth factor-alpha and the expression of various growth factors in neoplastic and non-neoplastic prostatic cell lines.
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