Sok, Chhon Ling, Rossjohn, Jamie  ORCID: https://orcid.org/0000-0002-2020-7522 and Gully, Benjamin S.
2024.
The evolving portrait of γδ TCR recognition determinants.
The Journal of Immunology
213
(5)
, pp. 543-552.
10.4049/jimmunol.2400114
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Abstract
In αβ T cells, immunosurveillance is enabled by the αβ TCR, which corecognizes peptide, lipid, or small-molecule Ags presented by MHC- and MHC class I–like Ag-presenting molecules, respectively. Although αβ TCRs vary in their Ag recognition modes, in general they corecognize the presented Ag and the Ag-presenting molecule and do so in an invariable “end-to-end” manner. Quite distinctly, γδ T cells, by way of their γδ TCR, can recognize ligands that extend beyond the confines of MHC- and MHC class I–like restrictions. From structural studies, it is now becoming apparent that γδ TCR recognition modes can break the corecognition paradigm and deviate markedly from the end-to-end docking mechanisms of αβ TCR counterparts. This brief review highlights the emerging portrait of how γδ TCRs can recognize diverse epitopes of their Ags in a manner reminiscent to how Abs recognize Ags.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | American Association of Immunologists |
| ISSN: | 0022-1767 |
| Date of First Compliant Deposit: | 28 April 2025 |
| Date of Acceptance: | 14 June 2024 |
| Last Modified: | 01 Sep 2025 01:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/175315 |
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