The evolving portrait of γδ TCR recognition determinants

Sok, Chhon Ling, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Gully, Benjamin S. 2024. The evolving portrait of γδ TCR recognition determinants. The Journal of Immunology 213 (5) , pp. 543-552. 10.4049/jimmunol.2400114

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Abstract

In αβ T cells, immunosurveillance is enabled by the αβ TCR, which corecognizes peptide, lipid, or small-molecule Ags presented by MHC- and MHC class I–like Ag-presenting molecules, respectively. Although αβ TCRs vary in their Ag recognition modes, in general they corecognize the presented Ag and the Ag-presenting molecule and do so in an invariable “end-to-end” manner. Quite distinctly, γδ T cells, by way of their γδ TCR, can recognize ligands that extend beyond the confines of MHC- and MHC class I–like restrictions. From structural studies, it is now becoming apparent that γδ TCR recognition modes can break the corecognition paradigm and deviate markedly from the end-to-end docking mechanisms of αβ TCR counterparts. This brief review highlights the emerging portrait of how γδ TCRs can recognize diverse epitopes of their Ags in a manner reminiscent to how Abs recognize Ags.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Date of Acceptance:	14 June 2024
Last Modified:	16 Jan 2025 11:15
URI:	https://orca.cardiff.ac.uk/id/eprint/175315

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