The molecular assembly of the marsupial γµ T cell receptor defines a third T cell lineage

Morrissey, Kimberly A., Wegrecki, Marcin, Praveena, T., Hansen, Victoria L., Bu, Lijing, Sivaraman, Komagal Kannan, Darko, Samuel, Douek, Daniel C., Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Miller, Robert D. and Le Nours, Jérôme 2021. The molecular assembly of the marsupial γµ T cell receptor defines a third T cell lineage. Science 371 (6536) , pp. 1383-1388. 10.1126/science.abe7070

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Abstract

αβ and γδ T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of γμTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vγ-Cγ) γ-chain paired to a three-domain (Vμ-Vμj-Cμ) μ-chain. γμTCRs were characterized by restricted diversity in the Vγ and Vμj domains and a highly diverse unpaired Vμ domain. Crystal structures of two distinct γμTCRs revealed the structural basis of the association of the γμTCR heterodimer. The Vμ domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3μ loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the γμTCR.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Date of First Compliant Deposit:	14 March 2025
Date of Acceptance:	4 February 2021
Last Modified:	14 Mar 2025 11:15
URI:	https://orca.cardiff.ac.uk/id/eprint/176874

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