Morrissey, Kimberly A., Wegrecki, Marcin, Praveena, T., Hansen, Victoria L., Bu, Lijing, Sivaraman, Komagal Kannan, Darko, Samuel, Douek, Daniel C., Rossjohn, Jamie  ORCID: https://orcid.org/0000-0002-2020-7522, Miller, Robert D. and Le Nours, Jérôme
2021.
The molecular assembly of the marsupial γµ T cell receptor defines a third T cell lineage.
Science
371
(6536)
, pp. 1383-1388.
10.1126/science.abe7070
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Abstract
αβ and γδ T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of γμTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vγ-Cγ) γ-chain paired to a three-domain (Vμ-Vμj-Cμ) μ-chain. γμTCRs were characterized by restricted diversity in the Vγ and Vμj domains and a highly diverse unpaired Vμ domain. Crystal structures of two distinct γμTCRs revealed the structural basis of the association of the γμTCR heterodimer. The Vμ domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3μ loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the γμTCR.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | American Association for the Advancement of Science |
| ISSN: | 0036-8075 |
| Date of First Compliant Deposit: | 14 March 2025 |
| Date of Acceptance: | 4 February 2021 |
| Last Modified: | 14 Mar 2025 11:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/176874 |
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