The senescent synapse: A look at autophagy, calcium handling, and mitochondrial bioenergetics at the synapse in ageing and Parkinson's disease

Mukhtar, Shahzabe, Kataria, Shikha, Cimaglia, Gloria and Beccano-Kelly, Dayne ORCID: https://orcid.org/0000-0003-3592-8354 2025. The senescent synapse: A look at autophagy, calcium handling, and mitochondrial bioenergetics at the synapse in ageing and Parkinson's disease. Current Research in Physiology 8 , 100166. 10.1016/j.crphys.2025.100166

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Abstract

The synapse is a vitally important physiological structure fundamental to electrochemical communication between neurones, and is required for basic and important functions we perform daily. Underpinning the normal physiological function of the synapse are crucial processes such as autophagy, calcium homeostasis, and mitochondrial bioenergetics, all of which are modified during ageing. It is necessary to understand how ageing affects these processes at the synapse, from a fundamental need to understand natural ageing, and in order to identify how these processes may become aberrant and indeed, pathological, in the context of ageing-related disorders, such as Parkinson's. This review addresses the importance of the aforementioned processes, autophagy, calcium homeostasis, and mitochondrial bioenergetics at the synapse in normal physiology, and discusses how they are altered during ageing, and in Parkinson's, an example of accelerated ageing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
ISSN:	2665-9441
Date of First Compliant Deposit:	20 October 2025
Date of Acceptance:	23 September 2025
Last Modified:	20 Oct 2025 14:15
URI:	https://orca.cardiff.ac.uk/id/eprint/181771

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