A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

Davies, Luke Cynlais, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Smith, Paul James, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41 (8) , pp. 2155-2164. 10.1002/eji.201141817

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Abstract

Macrophage (MØ) biology is routinely modelled in the peritoneal cavity, a vascular tissue readily infiltrated by leukocytes during inflammation. After several decades of study, no consensus has emerged regarding the importance of in situ proliferation versus peripheral monocyte recruitment for the maintenance of tissue resident MØs. By applying specific measures of mitosis, we have monitored tissue MØ proliferation during newborn development, adulthood and acute resolving inflammation in young adult mice. Despite the vascular nature of the tissue and ease of peripheral leukocyte entry, tissue MØs in the newborn increase in number by local proliferation. On the contrary, in the adult, tissue MØ proliferation is considerably reduced and most likely provides homeostatic control of cell numbers. Importantly, during an acute inflammatory response, when substantial numbers of inflammatory MØs are recruited from the circulation, tissue-resident MØs survive and then undergo a transient and intense proliferative burst in situ to repopulate the tissue. Our data indicate that local proliferation is a general mechanism for the self-sufficient renewal of tissue MØs during development and acute inflammation and not one restricted to non-vascular tissues, which has implications for the therapeutic modulation of MØ activity during the resolution of inflammation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Cellular proliferation; Inflammation; Macrophages
Publisher:	John Wiley & Sons
ISSN:	0014-2980
Last Modified:	17 Nov 2023 02:06
URI:	https://orca.cardiff.ac.uk/id/eprint/22579

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