Translational Mini-Review Series on B Cell-Directed Therapies: B cell-directed therapy for autoimmune diseases

Hu, C., Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, L. 2009. Translational Mini-Review Series on B Cell-Directed Therapies: B cell-directed therapy for autoimmune diseases. Clinical and Experimental Immunology 157 (2) , pp. 181-190. 10.1111/j.1365-2249.2009.03977.x

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Abstract

B cells play an important role in the pathogenesis of both systemic and organspecific autoimmune diseases. Autoreactive B cells not only produce autoantibodies, but are also specialized to present specific autoantigens efficiently to T cells. Furthermore, these B cells can secrete proinflammatory cytokines and can amplify the vicious cycle of self-destruction. Thus, B cell-directed therapies are potentially an important approach for treating autoimmune diseases. On the other hand, like T cells, there are subsets of B cells that produce anti-inflammatory cytokines and are immunosuppressive. These regulatory B cell subsets can protect against and ameliorate autoimmune diseases. Thus targeting B cells therapeutically will require this balance to be considered.Here we summarize the roles of pathogenic and regulatory B cells and current applications of B cell-directed therapy in autoimmune diseases. Considerations for future development of B cell-directed therapy for autoimmune diseases have also been discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General)
Uncontrolled Keywords:	autoimmune disease, B cell, immunotherapy
Publisher:	Wiley-Blackwell
ISSN:	0009-9104
Last Modified:	20 Oct 2022 07:45
URI:	https://orca.cardiff.ac.uk/id/eprint/26296

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