Hu, C., Wong, Florence Susan  ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, L.
2009.
Translational Mini-Review Series on B Cell-Directed Therapies: B cell-directed therapy for autoimmune diseases.
Clinical and Experimental Immunology
157
(2)
, pp. 181-190.
10.1111/j.1365-2249.2009.03977.x
|
Abstract
B cells play an important role in the pathogenesis of both systemic and organspecific autoimmune diseases. Autoreactive B cells not only produce autoantibodies, but are also specialized to present specific autoantigens efficiently to T cells. Furthermore, these B cells can secrete proinflammatory cytokines and can amplify the vicious cycle of self-destruction. Thus, B cell-directed therapies are potentially an important approach for treating autoimmune diseases. On the other hand, like T cells, there are subsets of B cells that produce anti-inflammatory cytokines and are immunosuppressive. These regulatory B cell subsets can protect against and ameliorate autoimmune diseases. Thus targeting B cells therapeutically will require this balance to be considered.Here we summarize the roles of pathogenic and regulatory B cells and current applications of B cell-directed therapy in autoimmune diseases. Considerations for future development of B cell-directed therapy for autoimmune diseases have also been discussed.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General) |
| Uncontrolled Keywords: | autoimmune disease, B cell, immunotherapy |
| Publisher: | Wiley-Blackwell |
| ISSN: | 0009-9104 |
| Last Modified: | 20 Oct 2022 07:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/26296 |
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