Structural and biophysical determinants of ab T-cell antigen recognition

Bridgeman, John S., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Miles, John James, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135 (1) , pp. 9-18. 10.1111/j.1365-2567.2011.03515.x

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Abstract

The molecular rules that govern MHC restriction, and allow T-cells to differentiate between peptides derived from healthy cells and those from diseased cells, remain poorly understood. Here we provide an overview of the structural constraints that enable the T-cell receptor (TCR) to discriminate between self and non-self peptides, and summarize studies that have attempted to correlate the biophysical parameters of TCR/peptide–major histocompatibility complex (pMHC) binding with T-cell activation. We further review how the antigenic origin of peptide epitopes affects TCR binding parameters and the ‘quality’ of a T-cell response. Understanding the principles that govern pMHC recognition by T-cells will unlock pathways to the rational development of immunotherapeutic approaches for the treatment of infectious disease, cancer and autoimmunity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	biophysics; crystal structure; peptide-major histocompatibility complex; T-cell activation; T-cell receptor
Publisher:	Wiley Blackwell
ISSN:	0019-2805
Last Modified:	10 Jun 2023 01:08
URI:	https://orca.cardiff.ac.uk/id/eprint/26503

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