Browse by Current Cardiff authors

Schwartz, John C., Farrell, Colin P., Freimanis, Graham, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Phillips, John D. and Hammond, John A. 2024. A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation. Immunogenetics 76 , pp. 361-380. 10.1007/s00251-024-01355-7

Dolton, Garry, Bulek, Anna, Wall, Aaron, Thomas, Hannah, Hopkins, Jade R, Rius, Cristina, Galloway, Sarah A.E., Whalley, Thomas, Tan, Li Rong, Morin, Theo, Omidvar, Nader, Fuller, Anna, Topley, Katie, Hasan, Samiul, Jain, Shika, D’Souza, Nirupa, Hodges-Hoyland, Tom, Spiller, Owen B. ORCID: https://orcid.org/0000-0002-9117-6911, Kronenberg-Versteeg, Deborah, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, van den Berg, Hugo A., Jones, Lucy C. ORCID: https://orcid.org/0000-0002-3872-4376, Peakman, Mark, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134 (18) , e164535. 10.1172/JCI164535

Ferrari, Mathieu, Righi, Matteo, Baldan, Vania, Wawrzyniecka, Patrycja, Bulek, Anna, Kinna, Alexander, Ma, Biao, Bughda, Reyisa, Akbar, Zulaikha, Srivastava, Saket, Gannon, Isaac, Robson, Mathew, Sillibourne, James, Jha, Ram, El-Kholy, Mohamed, Amin, Oliver Muhammad, Kokalaki, Evangelia, Banani, Mohammed Amin, Hussain, Rehan, Day, William, Lim, Wen Chean, Ghongane, Priyanka, Hopkins, Jade R., Jungherz, Dennis, Herling, Marco, Welin, Martin, Surade, Sachin, Dyson, Michael, McCafferty, John, Logan, Derek, Cordoba, Shaun, Thomas, Simon, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Maciocia, Paul, Onuoha, Shimobi and Pule, Martin 2024. Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies. Nature Communications 15 (1) , 1583. 10.1038/s41467-024-45854-3

Chen, Yuan, Mason, Georgina H., Scourfield, D. Oliver, Greenshields-Watson, Alexander, Haigh, Tracey A., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Long, Heather M., Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, MacLachlan, Bruce J. and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2023. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity. Cell Reports 42 (8) , 112827. 10.1016/j.celrep.2023.112827

Dolton, Garry, Rius, Cristina, Wall, Aaron, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Bianchi, Valentina, Galloway, Sarah A.E., Hasan, MD Samiul, Morin, Theo, Caillaud, Marine, Thomas, Hannah L., Theaker, Sarah, Tan, Li Rong, Fuller, Anna, Topley, Katie, Legut, Mateusz, Attaf, Merriem, Hopkins, Jade R., Behiry, Enas, Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, Alvares, Caroline ORCID: https://orcid.org/0000-0003-4391-9802, Lloyd, Angharad, Rogers, Amber, Henley, Peter, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330, Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686, Crowther, Michael D., Donia, Marco, Svane, Inge Marie, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Brown, Paul E., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186 (16) , pp. 3333-3349. 10.1016/j.cell.2023.06.020

Goncharov, Mikhail, Bagaev, Dmitry, Shcherbinin, Dmitrii, Zvyagin, Ivan, Bolotin, Dmitry, Thomas, Paul G., Minervina, Anastasia A., Pogorelyy, Mikhail V., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Nguyen, Thi H. O., Rowntree, Louise C., Clemens, E. Bridie, Kedzierska, Katherine, Dolton, Garry, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Samir, Jerome, Luciani, Fabio, Zornikova, Ksenia V., Khmelevskaya, Alexandra A., Sheetikov, Saveliy A., Efimov, Grigory A., Chudakov, Dmitry and Shugay, Mikhail 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9) , 1017–1019. 10.1038/s41592-022-01578-0

Dolton, Garry, Rius, Cristina, Hasan, Md Samiul, Wall, Aaron, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Behiry, Enas, Whalley, Thomas, Southgate, Joel, Fuller, Anna, Morin, Théo, Topley, Katie, Tan, Li Rong, Goulder, Philip J.R., Spiller, Owen B. ORCID: https://orcid.org/0000-0002-9117-6911, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Jones, Lucy C. ORCID: https://orcid.org/0000-0002-3872-4376, Connor, Thomas R. ORCID: https://orcid.org/0000-0003-2394-6504 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185 (16) , pp. 2936-2951. 10.1016/j.cell.2022.07.002

Martini, Veronica, Edmans, Matthew, Gubbins, Simon, Jayaraman, Siddharth, Paudyal, Basudev, Morgan, Sophie, McNee, Adam, Morin, Théo, Rijal, Pramila, Gerner, Wilhelm, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Inoue, Ryo, Bailey, Mick, Connelley, Timothy, Charleston, Bryan, Townsend, Alain, Beverley, Peter and Tchilian, Elma 2022. Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells. Mucosal Immunology 15 (3) , 428–442. 10.1038/s41385-021-00478-4

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Knezevic, Lea, Dockree, Tamsin, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, van den Berg, Hugo A. and Wooldridge, Linda 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118 (29) , e2019639118. 10.1073/pnas.2019639118

Crowther, Michael D. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2021. The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease. Current Opinion in Immunology 69 , pp. 10-17. 10.1016/j.coi.2020.12.002

Edmans, Matthew, McNee, Adam, Porter, Emily, Vatzia, Eleni, Paudyal, Basu, Martini, Veronica, Gubbins, Simon, Francis, Ore, Harley, Ross, Thomas, Amy, Burt, Rachel, Morgan, Sophie, Fuller, Anna, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Charleston, Bryan, Bailey, Mick and Tchilian, Elma 2021. Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in inbred Babraham pigs and outbred pigs. Frontiers in Immunology 11 , 604913. 10.3389/fimmu.2020.604913

Martini, Veronica, Paudyal, Basu, Chrun, Tiphany, McNee, Adam, Edmans, Matthew, Atangana Maze, Emmanuel, Clark, Beckie, Nunez, Alejandro, Dolton, Garry, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Beverley, Peter, MacLoughlin, Ronan, Townsend, Alain and Tchilian, Elma 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206 (2) , ji2001086. 10.4049/jimmunol.2001086

Hopkins, Jade R., Crean, Rory M., Catici, Dragana A. M., Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Arcus, Vickery L., Van der Kamp, Marc W., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Pudney, Christopher R. 2020. Peptide cargo tunes a network of correlated motions in human leukocyte antigens. FEBS Journal 287 (17) , pp. 3777-3793. 10.1111/febs.15278

Attaf, Meriem, Roider, Julia, Malik, Amna, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Dolton, Garry, Predergast, Andrew J., Leslie, Alasdair, Ndung'u, Thumbi, Kløverpris, Henrik N., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Goulder, Philip J. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11 , 1587. 10.3389/fimmu.2020.01587

Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L. ORCID: https://orcid.org/0000-0003-0889-964X, Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew J. ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew J. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) , 107885. 10.1016/j.celrep.2020.107885

Tarbe, Marion, Miles, John J., Edwards, Emily S. J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Baker, Brian M. and Quideau, Stéphane 2020. Synthesis and biological evaluation of hapten-clicked analogues of the antigenic peptide Melan‐A/MART‐126(27L)‐35. ChemMedChem 15 (9) , pp. 799-807. 10.1002/cmdc.202000038

Yeo, L., Pujol-Autonell, I., Baptista, R., Eichmann, M., Kronenberg-Versteeg, D., Heck, S., Dolton, G., Sewell, A. K. ORCID: https://orcid.org/0000-0003-3194-3135, Härkönen, T., Mikk, M.L., Toppari, J., Veijola, R., Knip, M., Ilonen, J. and Peakman, M. 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199 (3) , pp. 263-277. 10.1111/cei.13391

Crowther, Michael D., Dolton, Garry, Legut, Mateusz, Caillaud, Marine E., Lloyd, Angharad, Attaf, Meriem, Galloway, Sarah A. E., Rius, Cristina, Farrell, Colin P., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761, Fuller, Anna, Donia, Marco, McCluskey, James, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Svane, Inge Marie, Phillips, John D. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21 , 178 - 185. 10.1038/s41590-019-0578-8

Whalley, Thomas, Dolton, Garry, Brown, Paul E., Wall, Aaron, Wooldridge, Linda, van den Berg, Hugo, Fuller, Anna, Hopkins, Jade R., Crowther, Michael D., Attaf, Meriem, Knight, Robin R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11 , 296. 10.3389/fimmu.2020.00296

Bagaev, Dmitry V, Vroomans, Renske M A, Samir, Jerome, Stervbo, Ulrik, Rius, Cristina, Dolton, Garry, Greenshields Watson, Alexander, Attaf, Meriem, Egorov, Evgeny S, Zvyagin, Ivan V, Babel, Nina, Cole, David K ORCID: https://orcid.org/0000-0003-0028-9396, Godkin, Andrew J ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Kesmir, Can, Chudakov, Dmitriy M, Luciani, Fabio and Shugay, Mikhail 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48 (D1) , D1057-D1062. 10.1093/nar/gkz874

MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Elliott, Tim, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52) , pp. 20246-20258. 10.1074/jbc.RA119.009437

Kim, Aeryon, Han, Chia-Jung, Driver, Ian, Olow, Aleksandra, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Zhang, Zemin, Ouyang, Wenjun, Egen, Jackson G. and Yu, Xin 2019. LILRB1 blockade enhances bispecific T cell engager antibody-induced tumor cell killing by effector CD8+ T cells. Journal of Immunology 203 (4) , pp. 1076-1087. 10.4049/jimmunol.1801472

Madura, Florian, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49 (7) , pp. 1052-1066. 10.1002/eji.201948085

Galloway, Sarah A. E., Dolton, Garry, Attaf, Meriem, Wall, Aaron, Fuller, Anna, Rius, Cristina, Bianchi, Valentina, Theaker, Sarah, Lloyd, Angharad, Caillaud, Marine E., Svane, Inge Marie, Donia, Marco, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10 , 319. 10.3389/fimmu.2019.00319

Attaf, Meriem, Malik, Amna, Severinsen, Mai C., Roider, Julia, Ogongo, Paul, Buus, Søren, Ndung'u, Thumbi, Leslie, Alasdair, Kløverpris, Henrik N., Matthews, Philippa C., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Goulder, Philip 2018. Major TCR repertoire perturbation by immunodominant HLA-B*44:03 - restricted CMV - specific T cells. Frontiers in Immunology , 2539. 10.3389/fimmu.2018.02539

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Legut, Mateusz 2018. Designer T-cells and T-cell receptors for customised cancer immunotherapies. Current Opinion in Pharmacology 41 , pp. 96-103. 10.1016/j.coph.2018.05.005

Yeo, Lorraine, Woodwyk, Alyssa, Sood, Sanjana, Lorenc, Anna, Eichmann, Martin, Pujol-Autonell, Irma, Melchiotti, Rosella, Skowera, Ania, Fidanis, Efthymios, Dolton, Garry M., Tungatt, Katie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Heck, Susanne, Saxena, Alka, Beam, Craig A. and Peakman, Mark 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128 (8) , pp. 3460-3474. 10.1172/JCI120555

Zhao, Xiang, Sankaran, Shvetha, Yap, Jiawei, Too, Chien Tei, Ho, Zi Zong, Dolton, Garry, Legut, Mateusz, Ren, Ee Chee, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bertoletti, Antonio, MacAry, Paul A., Brzostek, Joanna and Gascoigne, Nicholas R. J. 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9 , 2716. 10.1038/s41467-018-05288-0

Dolton, Garry, Zervoudi, Efthalia, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Wall, Aaron, Thomas, Hannah L., Fuller, Anna, Yeo, Lorraine, Legut, Mateusz, Wheeler, Sophie, Attaf, Meriem, Chudakov, Dmitriy M., Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Peakman, Mark and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9 , 1378. 10.3389/fimmu.2018.01378

Tungatt, Katie, Dolton, Garry, Morgan, Sophie B., Attaf, Meriem, Fuller, Anna, Whalley, Thomas, Hemmink, Johanneke D., Porter, Emily, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Montoya, Maria, Hammond, John A., Miles, John J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Townsend, Alain, Bailey, Mick, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Charleston, Bryan, Tchilian, Elma and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) , e1007017. 10.1371/journal.ppat.1007017

Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wells, Stephen and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 , 674. 10.3389/fimmu.2018.00674

Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Makinde, Julia, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gras, Stephanie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Burrows, Scott R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512

Rius, Cristina, Attaf, Meriem, Tungatt, Katie, Bianchi, Valentina, Legut, Mateusz, Bovay, Amandine, Donia, Marco, Straten, Per thor, Peakman, Mark, Svane, Inge Marie, Ott, Sascha, Connor, Tom ORCID: https://orcid.org/0000-0003-2394-6504, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Dolton, Garry and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200 (7) , pp. 2263-2279. 10.4049/jimmunol.1700242

Bovay, Amandine, Zoete, Vincent, Dolton, Garry, Bulek, Anna M., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Michielin, Olivier, Speiser, Daniel E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Fuertes Marraco, Silvia A. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2) , pp. 258-272. 10.1002/eji.201747082

Legut, Mateusz, Dolton, Garry, Mian, Afsar, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131 (3) , pp. 311-322. 10.1182/blood-2017-05-787598

Shugay, M., Bagaev, D. V., Zvyagin, I. V., Vroomans, R. M., Crawford, J. C., Dolton, Garry M., Komech, Ekaterina A., Sycheva, Anastasiya L., Koneva, Anna E., Egorov, Evgeniy S., Eliseev, Alexey V., Van Dyk, E., Dash, P., Attaf, Meriem, Ruis, Cristina, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Clemens, Ella B., Douek, Daniel C., Luciani, Fabio, Van Baarle, D., Kedzierska, Katherine, Kesmir, Can, Thomas, Paul G., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Chudakov, Dimitry M. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46 (D1) , D419-D427. 10.1093/nar/gkx760

Maciocia, Paul M., Wawrzyniecka, Patrycja A., Philip, Brian, Ricciardelli, Ida, Akarca, Ayse U., Onuoha, Shimobi C., Legut, Mateusz, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gritti, Giuseppe, Somja, Joan, Piris, Miguel A., Peggs, Karl S., Linch, David C., Marafioti, Teresa and Pule, Martin A. 2017. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. Nature Medicine 23 , pp. 1416-1423. 10.1038/nm.4444

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Tan, M., Dolton, Garry Michael, Gerry, Andrew B., Brewer, Joanna E., Bennett, Alan D., Pumphrey, Nick, Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187 (1) , pp. 124-137. 10.1111/cei.12828

Attaf, Meriem and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2016. Disease etiology and diagnosis by TCR repertoire analysis goes viral. European Journal of Immunology 46 (11) , pp. 2516-2519. 10.1002/eji.201646649

Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuanqing, Bridgeman, John S, Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D, Tungatt, Katie, Dolton, Garry, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Price, David A ORCID: https://orcid.org/0000-0001-9416-2737, Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Gaus, Katharina 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113 (37) , E5454-E5463. 10.1073/pnas.1607436113

Hanson, W. Miachel, Chen, Zhe, Jackson, Laurie K., Attaf, Meriem, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Heemstra, Jennifer M. and Phillips, John D. 2016. Reversible oligonucleotide chain blocking enables bead capture and amplification of T-Cell receptor alpha and beta chain mRNAs. Journal of the American Chemical Society 138 (35) , pp. 11073-11076. 10.1021/jacs.6b04465

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Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W., Crowther, Michael D., Connor, Thomas ORCID: https://orcid.org/0000-0003-2394-6504, Dolton, Garry Michael, Miles, John James, Burrows, Scott R., Gold, Marielle C., Lewinsohn, David M. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197 (3) , pp. 971-982. 10.4049/jimmunol.1501402

Meermeier, Erin W., Laugel, Bruno F., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Corbett, Alexandra J., Rossjohn, Jamie, McCluskey, James, Harriff, Melanie J., Franks, Tamera, Gold, Marielle C. and Lewinsohn, David M. 2016. Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens. Nature Communications 7 , 12506. 10.1038/ncomms12506

Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Liu, Jie, Brown, Paul E., Miles, John J., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Llewellyn-Lacey, Sian, Dolton, Garry, Ekeruche-Makinde, Julia, Lissina, Anya, Schauenburg, Andrea J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Roederer, Mario, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and van den Berg, Hugo A. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94 (6) , pp. 573-582. 10.1038/icb.2016.12

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Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Dolton, Garry, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291 (17) , pp. 8951-8959. 10.1074/jbc.M115.707414

Theaker, Sarah M., Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew R., Fuller, Anna, Miles, John James, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Dolton, Garry Michael 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp. 43-50. 10.1016/j.jim.2016.01.014

Tsai, M.-H., Muenchhoff, M., Adland, E., Carlqvist, A., Roider, J., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Carlson, J., Ndung'u, T. and Goulder, P. J. R. 2016. Paediatric non-progression following grandmother-to-child HIV transmission. Retrovirology 13 (1) , p. 65. 10.1186/s12977-016-0300-y

Holland, Christopher J., Dolton, Garry M., Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Schauenburg, Andrea J., Miners, Kelly, Madura, Florian, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew J. ORCID: https://orcid.org/0000-0002-1910-7567 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12) , pp. 5827-5836. 10.4049/jimmunol.1402787

Dolton, Garry Michael, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew R., Holland, Christopher J., Donia, Marco, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Straten, Per Thor, Peakman, Mark, Svane, Inge Marie and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1) , pp. 11-22. 10.1111/imm.12499

Neller, Michelle A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van Baarle, Debbie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17

Motozono, Chihiro, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, De Leenheer, Evy, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Trimby, Andrew, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290 (31) , pp. 18924-18933. 10.1074/jbc.M114.622522

Attaf, Meriem, Legut, Mateusz, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. The T cell antigen receptor: the Swiss army knife of the immune. Clinical and Experimental Immunology 181 (1) , pp. 1-18. 10.1111/cei.12622

Motozono, Chihiro, Bridgeman, John S., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Ueno, T. 2015. Clonotypically similar hybrid ab T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clinical and Experimental Immunology 180 (3) , pp. 560-570. 10.1111/cei.12610

Gilham, David Edward, Anderson, John, Bridgeman, John Stephen, Hawkins, Robert Edward, Exley, Mark Adrian, Stauss, Hans, Maher, John, Pule, Martin, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bendle, Gavin, Lee, Steven, Qasim, Waseem, Thrasher, Adrian and Morris, Emma 2015. Adoptive t-cell therapy for cancer in the United Kingdom: a review of activity for the British Society of Gene and Cell Therapy Annual Meeting 2015. Human Gene Therapy 26 (5) , pp. 276-285. 10.1089/hum.2015.024

Skowera, Ania, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Dolton, Garry Michael, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin Mark ORCID: https://orcid.org/0000-0002-6557-3462, Miles, John J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Peakman, Mark 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332

Madura, Florian, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Holland, Christopher J., Fuller, Anna, Bulek, Anna Marta, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Schauenburg, Andrea J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45 (2) , pp. 584-591. 10.1002/eji.201445114

Straetemans, Trudy, Berrevoets, Cor, Coccoris, Miriam, Treffers-Westerlaken, Elike, Wijers, Rebecca, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dardalhon, Valerie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Taylor, Naomi, Verweij, Jaap and Debets, Reno 2015. Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment. Molecular Therapy 23 (2) , pp. 396-406. 10.1038/mt.2014.215

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Knight, R. R., Dolton, Garry Michael, Kronenberg-Versteeg, D., Eichmann, M., Zhao, M., Huang, G. C., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Skowera, A. and Peakman, M. 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179 (1) , pp. 100-107. 10.1111/cei.12436

Attaf, Meriem, Huseby, Eric and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. αβ T cell receptors as predictors of health and disease. Cellular and Molecular Immunology 12 , pp. 391-399. 10.1038/cmi.2014.134

Legut, Mateusz, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy. Cellular and Molecular Immunology 12 , pp. 656-668. 10.1038/cmi.2015.28

Kløverpris, Henrik N., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Fuller, Anna, Carlson, Jonathan, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Schauenburg, Andrea J. A., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Buus, Søren, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Goulder, Philip 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12 (1) , 20. 10.1186/s12977-015-0149-5

Tan, Mai, Gerry, A. B., Brewer, J. E., Melchiori, L., Bridgeman, John S., Bennett, A. D., Pumphrey, N. J., Jakobsen, B. K., Price, D. A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2014. T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells. Clinical and Experimental Immunology 180 (2) , pp. 255-270. 10.1111/cei.12570

Stepanek, Ondrej, Prabhakar, Arvind S., Osswald, Celine, King, Carolyn G., Bulek, Anna Marta, Naeher, Dieter, Beaufils-Hugot, Marina, Abanto, Michael L., Galati, Virginie, Hausmann, Barbara, Lang, Rosemarie, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Huseby, Eric S., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Chakraborty, Arup K. and Palmer, Ed 2014. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell 159 (2) , pp. 333-345. 10.1016/j.cell.2014.08.042

Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Neller, M. A., Miles, John James, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Peakman, M. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339

Motozono, Chihiro, Kuse, N, Sun, X., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Oka, S., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Takiguchi, M. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192 (7) , pp. 3428-3434. 10.4049/jimmunol.1302667

Bhati, Mugdha, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, McCluskey, James, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 2014. The versatility of the αβ T-cell antigen receptor. Protein Science 23 (3) , pp. 260-272. 10.1002/pro.2412

van den Berg, Hugo A., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S. and Price, David ORCID: https://orcid.org/0000-0001-9416-2737 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4 , 250. 10.3389/fimmu.2013.00250

Madura, Florian, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Miles, Kim Michelle, Holland, Christopher J., Bulek, Anna Marta, Fuller, Anna, Schauenburg, Andrea J. A., Miles, John James, Liddy, Nathaniel, Sami, M., Li, Y., Hossain, M., Baker, B. M., Jakobsen, B. K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288 (26) , pp. 18766-18775. 10.1074/jbc.M113.464560

Pentier, Johanne M., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Miles, John James 2013. Advances in T-Cell Epitope Engineering. Frontiers in Immunology 4 , 133. 10.3389/fimmu.2013.00133

Motozono, Chihiro, Miles, John J., Hasan, Zafrul, Gatanaga, Hiroyuki, Meribe, Stanley C., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Oka, Shinichi, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Ueno, Takamasa 2013. CD8+ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE 8 (6) , e66152. 10.1371/journal.pone.0066152

Challier, John, Bruniquel, Denis, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Laugel, Bruno 2013. Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity. Immunology 138 (4) , pp. 402-410. 10.1111/imm.12053

Xu, Weidong, Watts, Douglas M., Costanzo, Margaret C., Tang, Xiaolei, Venegas, Leon A., Jiao, Feng, Sette, Alessandro, Sidney, John, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wooldridge, Linda, Makino, Shinji, Morrill, John C., Peters, Clarence J. and Kan-Mitchell, June 2013. The nucleocapsid protein of rift valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses. PLoS ONE 8 (3) , e59210. 10.1371/journal.pone.0059210

Welton, Joanne, Morgan, Matthew, Martí, Salvador, Stone, Michael, Moser, Bernhard ORCID: https://orcid.org/0000-0002-4354-4572, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Turton, Jane and Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28 (3) , pp. 464-471. 10.1002/jbmr.1797

Eukeruche-Makinde, Julia, Miles, John J., Van Den Berg, Hugo A., Skowera, Ania, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea, Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Dockree, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Burrows, Scott, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Ekeruche, Julia, Miles, John James, van den Berg, Hugo A., Skowera, Ania, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea J. A., Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim Michelle, Bulek, Anna Marta, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Williams, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Burrows, Scott R., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Miles, Kim Michelle, Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Bulek, Anna Marta, Fuller, Anna, Akpovwa, Hephzibah, Pymm, Phillip G., Liddy, N., Sami, M., Li, Y., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Jakobsen, B. K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289 (2) , pp. 628-638. 10.1074/jbc.M113.522110

Knight, Robin R., Kronenberg, Deborah, Zhao, Min, Huang, Guo Cai, Eichmann, Martin, Bulek, Anna Marta, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Peakman, Mark and Skowera, Ania 2013. Human β-cell killing by autoreactive preproinsulin-specific cd8 t cells is predominantly granule-mediated with the potency dependent upon t-cell receptor avidity. Diabetes 62 (1) , pp. 205-213. 10.2337/db12-0315

Matthews, Philippa C., Koyanagi, Madoka, Kloverpris, Henrik N., Harndahl, Mikkel, Stryhn, Anette, Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Oka, Shinichi, Juarez Molina, Claudia, Valenzuela Ponce, Humberto, Avila Rios, Santiago, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Carlson, Jonathan, Payne, Rebecca P., Ogwu, Anthony, Bere, Alfred, Ndung'u, Thumbi, Gounder, Kamini, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Shapiro, Roger, Brander, Christian, Walker, Bruce, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Reyes Teran, Gustavo, Heckerman, David, Hunter, Eric, Buus, Søren, Takiguchi, Masafumi and Goulder, Philip J. R. 2012. Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single gag epitope. Journal of Virology 86 (23) , pp. 12643-12654. 10.1128/JVI.01381-12

Ekeruche, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Ekeruche-Makinde, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

Holland, Christopher J., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Stern, Lawrence J., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2 , 629. 10.1038/srep00629

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. Why must T cells be cross-reactive? Nature Reviews Immunology 12 (9) , pp. 669-677. 10.1038/nri3279

Bulek, Anna Marta, Madura, Florian, Fuller, Anna, Holland, Christopher J., Schauenburg, Andrea J. A., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382 (1-2) , pp. 203-210. 10.1016/j.jim.2012.06.007

Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J., Lissina, Anna, Mahon, Tara M., Hassan, Namir J., Gavarret, Jessie, Bianchi, Frayne C., Pumphrey, Nicholas J., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Gostick, Emma, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Lissin, Nikolai M., Harwood, Naomi E., Molloy, Peter E., Li, Yi, Cameron, Brian J., Sami, Malkit, Baston, Emma E., Todorov, Penio T., Paston, Samantha J., Dennis, Rebecca E., Harper, Jane V., Dunn, Steve M., Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H., Kalos, Michael, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Vuidepot, Annelise, Williams, Daniel D., Sutton, Deborah H. and Jakobsen, Bent K 2012. Monoclonal TCR-redirected tumor cell killing. Nature Medicine 18 (6) , pp. 980-987. 10.1038/nm.2764

Bulek, Anna, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Drijfhout, Jan W, Knight, Robin R, Huang, Guo C, Lissin, Nikolai, Molloy, Peter E, Wooldridge, Linda, Jakobsen, Bent K, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Skowera, Ania, Dolton, Garry Michael, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John James, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gougeon, Marie-Lise and Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665

Wooldridge, Linda, Ekeruche, Julia, van den Berg, Hugo A., Skowera, Anna, Miles, John James, Tan, Mai Ping, Dolton, Garry Michael, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Llewellyn-Lacey, Sian, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Peakman, Mark and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287 (2) , pp. 1168-1177. 10.1074/jbc.M111.289488

Bridgeman, John S., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Miles, John James, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135 (1) , pp. 9-18. 10.1111/j.1365-2567.2011.03515.x

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Miles, John James, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Miles, Kim Michelle, Miles, John James, Madura, Florian, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 2011. Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology 48 (4) , pp. 728-732. 10.1016/j.molimm.2010.11.004

Laugel, Bruno Frederic, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90 (6) , pp. 1089-1099. 10.1189/jlb.0611316

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Wynn, Katherine, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Miles, John James, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4) , pp. 2600-2610. 10.4049/jimmunol.1000629

Wooldridge, Linda, Laugel, Bruno Frederic, Ekeruche, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185 (8) , pp. 4625-4632. 10.4049/jimmunol.1001480

Schaubert, Keri L., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Salkowitz, Janelle R., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Sidney, John, Asher, Tedi, Blondelle, Sylvie E., Adams, Sharon, Marincola, Francesco M., Joseph, Aviva, Sette, Alessandro, Douek, Daniel C., Ayyavoo, Velpandi, Storkus, Walter, Leung, Ming-Ying, Ng, Hwee, Yang, Otto O., Goldstein, Harris, Wilson, Darcy B. and Kan-Mitchell, June 2010. Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology 40 (7) , pp. 1950-1962. 10.1002/eji.200940079

Wooldridge, Linda, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Lissina, Anna, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7) , pp. 3357-3366. 10.4049/jimmunol.0902398

Chen, Ji-Li, Morgan, Anthony J., Stewart-Jones, Guillaume, Shepherd, Dawn, Bossi, Giovanna, Wooldridge, Linda, Hutchinson, Sarah L., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Griffiths, Gillian M., van der Merwe, P. Anton, Jones, E. Yvonne, Galione, Antony and Cerundolo, Vincenzo 2010. Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor. The Journal of Immunology 184 (4) , pp. 1829-1839. 10.4049/jimmunol.0902103

Walker, L. J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Klenerman, P. 2010. T cell sensitivity and the outcome of viral infection. Clinical and Experimental Immunology 159 (3) , pp. 245-255. 10.1111/j.1365-2249.2009.04047.x

Miles, John James, Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Schauenburg, Andrea J. A., Dolton, Garry Michael, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott R., Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6 (11) , e1001198. 10.1371/journal.ppat.1001198

Borbulevych, Oleg Y., Piepenbrink, Kurt H., Gloor, Brian E., Scott, Daniel R., Sommese, Ruth F., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Baker, Brian M. 2009. T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity 31 (6) , pp. 885-896. 10.1016/j.immuni.2009.11.003

Hoffman, M., Hickling, Steven, Filby, A., Wilburg, C., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Turner, A., Sims, S., McLean, Andrew, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Klenerman, P., Frater, J. and Phillips, R. E. 2009. Novel tetramer technology for the detection of high affinity CD8 T cells [Conference poster abstract]. Retrovirology 6 (S3) , P409. 10.1186/1742-4690-6-S3-P409

Lissina, Anna, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Skowera, Ania, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Seggewiss, Ruth, van den Berg, Hugo A., Gostick, Emma, Gallagher, Kathleen, Jones, Emma, Melenhorst, J. Joseph, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Peakman, Mark, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1) , pp. 11-24. 10.1016/j.jim.2008.09.014

Jo, J., Aichele, U., Kersting, N., Klein, R., Aichele, P., Bisse, E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Blum, H. E., Bartenschlager, R., Lohmann, V. and Thimme, R. 2009. Analysis of CD8+ T-Cell-Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model. Gastroenterology 136 (4) , pp. 1391-1401. 10.1053/j.gastro.2008.12.034

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Yuan, Fang, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Miles, John James, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gao, George F., Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284 (40) , 27281-27289. 10.1074/jbc.M109.022509

Choudhuri, K., Parker, M., Milicic, A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Shaw, M. K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Stewart-Jones, G., Dong, T., Gould, K. G. and van der Merwe, P. A. 2009. Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation. Journal of Biological Chemistry 284 (38) , pp. 26096-26105. 10.1074/jbc.M109.039966

Horlock, Claire, Stott, Bryony, Dyson, Julian, Ogg, Graham, McPherson, Tess, Jones, Louise, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Stebbing, Justin and Savage, Philip 2009. ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of Immunological Methods 350 (1-2) , pp. 150-160. 10.1016/j.jim.2009.08.011

Wooldridge, Linda, Lissina, Anna, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126 (2) , pp. 147-164. 10.1111/j.1365-2567.2008.02848.x

Varela-Rohena, Angel, Molloy, Peter E., Dunn, Steven M., Li, Yi, Suhoski, Megan M., Carroll, Richard G., Milicic, Anita, Mahon, Tara, Sutton, Deborah H., Laugel, Bruno, Moysey, Ruth, Cameron, Brian J., Vuidepot, Annelise, Purbhoo, Marco A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Phillips, Rodney E., June, Carl H., Jakobsen, Bent K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Riley, James L. 2008. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine 14 (12) , pp. 1390-1395. 10.1038/nm.1779

Skowera, Ania, Ellis, Richard J., Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S., Tree, Timothy I. M., Zhao, Min, Dayan, Colin Mark ORCID: https://orcid.org/0000-0002-6557-3462, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Unger, Wendy, Drijfhout, Jan W., Ossendorp, Ferry, Roep, Bart O. and Peakman, Mark 2008. CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. Journal of Clinical Investigation 118 (10) , pp. 3390-3402. 10.1172/JCI35449

Melenhorst, J. Joseph, Scheinberg, Phillip, Chattopadhyay, Pratip K., Lissina, Anna, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Wooldridge, Linda, van den Berg, Hugo A., Bornstein, Ethan, Hensel, Nancy F., Douek, Daniel C., Roederer, Mario, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Barrett, A. John and Price, David ORCID: https://orcid.org/0000-0001-9416-2737 2008. Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods 338 (1-2) , pp. 31-39. 10.1016/j.jim.2008.07.008

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dunn, Steven M., Sami, Malkit, Boulter, Jonathan M., Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2008. T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular Immunology 45 (9) , pp. 2700-2709. 10.1016/j.molimm.2007.12.009

Weichsel, Ralf, Dix, Carolin, Wooldridge, Linda, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fenton-May, Angharad, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Zezula, Josef, Greiner, Elizabeth, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Einsele, Hermann and Seggewiss, Ruth 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14 (8) , pp. 2484-2491. 10.1158/1078-0432.CCR-07-4393

Chattopadhyay, Pratip K., Melenhorst, J. Joseph, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Gostick, Emma, Scheinberg, Phillip, Barrett, A. John, Wooldridge, Linda, Roederer, Mario, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+T cells with peptide-major histocompatibility complex class I tetramers. Cytometry Part A 73A (11) , pp. 1001-1009. 10.1002/cyto.a.20642

Scriba, Thomas J., Sierro, Sophie, Brown, Eric L., Phillips, Rodney E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Massey, Ruth C. 2008. The staphyloccous aureus eap protein activates expression of proinflammatory cytokines. Infection and Immunity 76 (5) , pp. 2164-2168. 10.1128/IAI.01699-07

Kasprowicz, Victoria, Ward, Scott M., Turner, Alison, Grammatikos, Alexandros, Nolan, Brian E., Lewis-Ximenez, Lia, Sharp, Charles, Woodfruff, Jenny, Fleming, Vicki M., Sims, Stuart, Walker, Bruce D., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Lauer, Georg M. and Klenerman, Paul 2008. Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. Journal of Clinical Investigation 118 (3) , pp. 1143-1153. 10.1172/JCI33082

Laugel, Bruno Frederic, Berg, Hugo A. van den, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Wooldridge, Linda, Boulter, Jonathan M, Milicic, Anita, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties. The Journal of Biological Chemistry 282 (33) , pp. 23799-22810. 10.1074/jbc.M700976200

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Pumphrey, Nicholas J., Boulter, Jonathan M., Sami, Malkit, Bell, John I., Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gao, George F., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Jakobsen, Bent K. 2007. Human TCR-binding affinity is governed by MHC class restriction. The Journal of Immunology 178 (9) , pp. 5727-5734. 10.4049/​jimmunol.178.9.5727

Wooldridge, Linda, Lissina, Anna, Vernazza, Jonathan, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Mirza, Fareed, Dunbar, P. Rod, Boulter, Jonathan M., Glick, Meir, Cerundolo, Vincenzo, Berg, Hugo A. van den, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. European Journal of Immunology 37 (5) , pp. 1323-1333. 10.1002/eji.200636765

Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Hutchinson, Sarah L., Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno Frederic, Lissina, A., Oxenius, Annette, Boulter, Jonathan M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology 37 (2) , pp. 479-486. 10.1002/eji.200636243

Boulter, Jonathan M., Schmitz, Nicole, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Bachmann, Martin F. and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37 (3) , pp. 798-806. 10.1002/eji.200636743

Yuan, Fang, Georgiou, Theonie, Hillon, Theresa, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Moysey, Ruth, Gavarret, Jessie, Vuidepot, Annelise, Sami, Malkit, Bell, John I., Gao, George F., Rizkallah, Pierre J. and Jakobsen, Bent K. 2007. Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63 (9) , pp. 758-760. 10.1107/S1744309107037244

Schaubert, K. L., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Frahm, N., Li, J., Ng, H. L., Joseph, A., Paul, E., Majumder, B., Ayyavoo, V., Gostick, E., Adams, S., Marincola, F. M., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Altfeld, M., Brenchley, J. M., Douek, D. C., Yang, O. O., Brander, C., Goldstein, H. and Kan-Mitchell, J. 2007. Availability of a diversely Avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 gag p2419-27 epitope. The Journal of Immunology 178 (12) , pp. 7756-7766. 10.4049/jimmunol.178.12.7756

Laugel, Bruno, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Milicic, Anita and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2007. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. European Journal of Immunology 37 (4) , pp. 905-913. 10.1002/eji.200636718

Wooldridge, Linda, Scriba, Thomas J., Milicic, Anita, Laugel, Bruno Frederic, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Phillips, Rodney E. and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. European Journal of Immunology 36 (7) , pp. 1847-1855. 10.1002/eji.200635886

Laugel, Bruno, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2006. On the path to TCR-directed therapeutics. Nature Biotechnology 24 (6) , pp. 615-616. 10.1038/nbt0606-615b

Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Brenchley, Jason M., Ruff, Laura E., Betts, Michael R., Hill, Brenna J., Roederer, Mario, Koup, Richard A., Migueles, Steven A., Gostick, Emma, Wooldridge, Linda, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Connors, Mark and Douek, Daniel C. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Journal of Experimental Medicine 202 (10) , pp. 1349-61. 10.1084/jem.20051357

Wooldridge, Linda, Berg, Hugo A. van den, Glick, Meir, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Milicic, Anita, Brenchley, Jason M., Douek, Daniel C., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2005. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. The Journal of Biological Chemistry 280 (30) , pp. 27491-27501. 10.1074/jbc.M500555200

Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Philips, R., Walker, B. and Goulder, P. 2005. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. Journal of Experimental Medicine 201 (6) , pp. 891-902. 10.1084/jem.20041455

Laugel, B., Boulter, J. M., Lissin, N., Vuidepot, A., Gostick, E., Crotty, L. E., Douek, D. C., Hemelaar, J., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Jakobsen, B. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2005. Design of soluble recombinant T Cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry 280 (3) , pp. 1882-1892. 10.1074/jbc.M409427200

Rezvani, K., Brenchley, J. M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Kilical, Y., Gostick, E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Li, J., Mielke, S., Douek, D. C. and Barrett, A. J. 2005. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization. Clinical Cancer Research 11 (24) , pp. 8799-8807. 10.1158/1078-0432.CCR-05-1314

Hewitt, R. E., Lissina, A., Green, A. E., Slay, E. S., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2005. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clinical and Experimental Immunology 139 (1) , pp. 101-111. 10.1111/j.1365-2249.2005.02665.x

Green, A. E., Lissina, A., Hutchinson, S. L., Hewitt, R. E., Temple, B., James, D., Boulter, J. M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2004. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clinical & Experimental Immunology 136 (3) , pp. 472-482. 10.1111/j.1365-2249.2004.02472.x

Wooldridge, Linda, Hutchinson, Sarah L., Choi, Ed M., Lissina, Anna, Jones, Emma, Mirza, Fareed, Dunbar, P. Rod, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Cerundolo, Vincenzo and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171 , pp. 6650-60.

Glick, M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Vuidepot, A.-L., Andersen, T. B., Hutchinson, S. L., Laugel, B., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Boulter, J. M., Dunbar, P. R., Cerundolo, V., Oxenius, A., Bell, J. I., Richards, W. G. and Jakobsen, B. K. 2002. Novel CD8+ T cell antagonists based on 2-Microglobulin. Journal of Biological Chemistry 277 (23) , pp. 20840-20846. 10.1074/jbc.M201819200

Kelleher, Anthony D., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Price, David ORCID: https://orcid.org/0000-0001-9416-2737 2002. Dyslipidemia due to retroviral protease inhibitors [Letter]. Nature Medicine 8 (4) , p. 308. 10.1038/nm0402-308a

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, McMichael, A. J., Screaton, G. R. and Cerundolo, V. 2001. A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity 14 (5) , pp. 591-602. 10.1016/S1074-7613(01)00133-9

Oxenius, Annette, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Dawson, Sara J., Tun, Tin, Easterbrook, Philippa J., Phillips, Rodney E. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2001. Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS 15 (1) , pp. 121-122. 10.1097/00002030-200101050-00018

Purbhoo, M. A., Boulter, J. M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Vuidepot, A.-L., Hourigan, C. S., Dunbar, P. R., Olson, K., Dawson, S. J., Phillips, R. E., Jakobsen, B. K., Bell, J. I. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2001. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor chain. Journal of Biological Chemistry 276 (35) , pp. 32786-32792. 10.1074/jbc.M102498200

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Price, David ORCID: https://orcid.org/0000-0001-9416-2737 2001. Dendritic cells and transmission of HIV-1. Trends in Immunology 22 (4) , pp. 173-175. 10.1016/S1471-4906(01)01866-X

Oxenius, A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Phillips, R. E. 2000. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 97 (7) , pp. 3382-3387. 10.1073/pnas.97.7.3382

Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Klenerman, Paul, Booth, Bruce L, Phillips, Rodney E and Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135 1999. Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunology Today 20 (5) , pp. 212-216. 10.1016/S0167-5699(99)01447-4

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gerth, U. C., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Purbhoo, M. A., Boulter, J. M., Gao, G. F., Bell, J. I., Phillips, R. E. and Jakobsen, B. K. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5 , pp. 399-404. 10.1038/7398

Lewis, J. W., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Elliot, T. 1998. HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. European Journal of Immunology 28 , pp. 3214-3220.

Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Dong, Tao, Tan, Rusung, Goulder, Philip J. R., Rowland-Jones, Sarah L. and Phillips, Rodney E. 1998. Antigen-specific release of b-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Current Biology 8 (6) , pp. 355-358. 10.1016/S0960-9822(98)70138-1

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Harcourt, Gillian C., Goulder, Philip J. R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Phillips, Rodney E. 1997. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. European Journal of Immunology 27 (9) , pp. 2323-2329. 10.1002/eji.1830270929

Price, David ORCID: https://orcid.org/0000-0001-9416-2737, PJ, Goulder, P, Klenerman, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, PJ, Easterbrook, M, Troop, CR, Bangham and RE, Phillips 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proceedings of the National Academy of Sciences 94 (5) , pp. 1890-1895. 10.1073/pnas.94.5.1890