Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity

Chakraborty, Mallinath, McGreal, Eamon Patrick, Davies, Philip Lloyd, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104 (3) , pp. 161-167. 10.1159/000351015

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Abstract

Background: Interleukin-6 (IL-6) signalling involves the interplay between IL-6, soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130). IL-6 activity is modulated by the soluble receptors to produce both pro- and anti-inflammatory effects in human diseases and animal models. The expression and functional activity of these molecules in lungs of preterm ventilated infants is unknown. Objectives: We investigated this pathway in preterm infants who were at risk of developing chronic lung disease of prematurity (CLD). Methods: Cytokines and soluble receptors were measured in bronchoalveolar lavage fluid (BALF) from ventilated preterm infants ≤32 weeks of gestation who did or did not develop CLD. B9 cells, which specifically proliferate to IL-6, were used to assess BALF IL-6 functional activity. Results: Inflammatory cells, IL-8 and monocyte chemotactic protein-1 were increased in BALF from the CLD group when compared to the No CLD group (p < 0.05). BALF IL-6 and sIL-6R were similar in both groups. In contrast, BALF sgp130 and sgp130/sIL-6R were greater in the CLD group when compared to the No CLD group (p = 0.01 and p = 0.02, respectively). However, the increased BALF sgp130 did not appear to modulate the BALF IL-6 functional activity. Conclusion: Lung inflammation was observed in the CLD group. Increased BALF sgp130 was noted in the CLD group but it did not appear to modulate the pulmonary IL-6 bioactivity. Further research is needed to investigate the potential modulatory activity of sgp130 in the preterm lung.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RJ Pediatrics
Publisher:	Karger
ISSN:	1661-7819
Last Modified:	05 Feb 2025 22:36
URI:	https://orca.cardiff.ac.uk/id/eprint/50495

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