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Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia

Bowen, Timothy, Guy, Carol, Cardno, A. G., Vincent, J. B., Kennedy, J. L., Jones, L. A., Gray, M, Sanders, Rhys, McCarthy, G, Murphy, K. C., Owen, Michael John and O'Donovan, Michael Conlon 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10 (1) , pp. 33-37. 10.1097/00041444-200010010-00006

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A number of studies using the repeat expansion detection (RED) technique have suggested an association between unknown large CAG/CTG repeats and schizophrenia. The polymorphic CAG/CTG repeat loci CTG18.1 and ERDA1 have been reported to account for a high proportion (approximately 90%) of the large repeats detected by RED and may therefore be responsible for the cited association. The recently described locus TGC13-7a contains a highly polymorphic CTA/TAG and CAG/CTG composite repeat, and is thus another authentic candidate. In the present investigation, each locus was analysed for association with schizophrenia in a sample of 206 patients and 219 group-matched controls. No evidence for association of CTG18.1, ERDA1 and/or TGC13-7a with schizophrenia was found. The combined data accounted for only 54% of the CAG/CTG arrays of > 40 repeats found in our previous RED analysis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Adult, Case-Control Studies, DNA-Binding Proteins*, European Continental Ancestry Group / genetics, Female, Genetic Predisposition to Disease Genotype, Humans, Male, Middle Aged, Polymerase Chain Reaction, Schizophrenia /g enetics*, TCF Transcription Factors, Trans-Activators / genetics, Transcription Factor 7-Like 2 Protein, Transcription Factors*, Trinucleotide Repeats* Substances DNA-Binding Proteins,TCF Transcription Factors,TCF7L2 protein, human,Trans-Activators,Transcription Factor 7-Like 2 Protein,Transcription Factors
Additional Information: Publication Types Research Support, Non-U.S. Gov't Full Text Sources Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe Medical Schizophrenia - MedlinePlus Health Information
ISSN: 0955-8829
Last Modified: 14 Feb 2020 13:10

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