Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia

Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Guy, Carol, Cardno, A. G., Vincent, J. B., Kennedy, J. L., Jones, L. A., Gray, M, Sanders, Rhys, McCarthy, G, Murphy, K. C., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10 (1) , pp. 33-37. 10.1097/00041444-200010010-00006

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Abstract

A number of studies using the repeat expansion detection (RED) technique have suggested an association between unknown large CAG/CTG repeats and schizophrenia. The polymorphic CAG/CTG repeat loci CTG18.1 and ERDA1 have been reported to account for a high proportion (approximately 90%) of the large repeats detected by RED and may therefore be responsible for the cited association. The recently described locus TGC13-7a contains a highly polymorphic CTA/TAG and CAG/CTG composite repeat, and is thus another authentic candidate. In the present investigation, each locus was analysed for association with schizophrenia in a sample of 206 patients and 219 group-matched controls. No evidence for association of CTG18.1, ERDA1 and/or TGC13-7a with schizophrenia was found. The combined data accounted for only 54% of the CAG/CTG arrays of > 40 repeats found in our previous RED analysis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Adult, Case-Control Studies, DNA-Binding Proteins*, European Continental Ancestry Group / genetics, Female, Genetic Predisposition to Disease Genotype, Humans, Male, Middle Aged, Polymerase Chain Reaction, Schizophrenia /g enetics*, TCF Transcription Factors, Trans-Activators / genetics, Transcription Factor 7-Like 2 Protein, Transcription Factors*, Trinucleotide Repeats* Substances DNA-Binding Proteins,TCF Transcription Factors,TCF7L2 protein, human,Trans-Activators,Transcription Factor 7-Like 2 Protein,Transcription Factors
Additional Information:	Publication Types Research Support, Non-U.S. Gov't Full Text Sources Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe Medical Schizophrenia - MedlinePlus Health Information
ISSN:	0955-8829
Last Modified:	12 Dec 2022 08:54
URI:	https://orca.cardiff.ac.uk/id/eprint/57924

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