Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA

Edwards, Richard, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Daniels, Stephen and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2015. Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA. European Journal of Organic Chemistry 2015 (3) , pp. 625-630. 10.1002/ejoc.201403378

Preview

PDF - Accepted Post-Print Version Download (395kB) | Preview

Abstract

[18F]F-DOPA is an important radiotracer that is used in the diagnosis of Parkinson's disease and neuroendocrine tumours. We describe a simple synthesis for a number of diaryliodonium salt precursors that are suitable for the production of [18F]F-DOPA through reaction with no carrier added (n.c.a.) nucleophilic [18F]fluoride. The simple procedure gives bench-stable, complex iodonium precursors in good yields without the need for laborious anhydrous conditions. Further alteration to the precursor counterion can be readily achieved for a range of halides and pseudo halides by a simple modification of the workup. Preliminary “hot” and “cold” fluorination results show the suitability of the compounds for the production of [18F]F-DOPA.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Pharmacy
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Analytical methods / Isotopic labeling / Imaging agents / Fluorination / PET / Radiochemistry
Publisher:	Wiley
ISSN:	1434-193X
Date of First Compliant Deposit:	31 March 2017
Date of Acceptance:	9 December 2014
Last Modified:	17 Nov 2024 03:30
URI:	https://orca.cardiff.ac.uk/id/eprint/68275

Citation Data

Cited 25 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item