Edwards, Richard, Westwell, Andrew D.  ORCID: https://orcid.org/0000-0002-5166-9236, Daniels, Stephen and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667
2015.
Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA.
European Journal of Organic Chemistry
2015
(3)
, pp. 625-630.
10.1002/ejoc.201403378
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Abstract
[18F]F-DOPA is an important radiotracer that is used in the diagnosis of Parkinson's disease and neuroendocrine tumours. We describe a simple synthesis for a number of diaryliodonium salt precursors that are suitable for the production of [18F]F-DOPA through reaction with no carrier added (n.c.a.) nucleophilic [18F]fluoride. The simple procedure gives bench-stable, complex iodonium precursors in good yields without the need for laborious anhydrous conditions. Further alteration to the precursor counterion can be readily achieved for a range of halides and pseudo halides by a simple modification of the workup. Preliminary “hot” and “cold” fluorination results show the suitability of the compounds for the production of [18F]F-DOPA.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry Schools > Pharmacy |
| Subjects: | Q Science > QD Chemistry |
| Uncontrolled Keywords: | Analytical methods / Isotopic labeling / Imaging agents / Fluorination / PET / Radiochemistry |
| Publisher: | Wiley |
| ISSN: | 1434-193X |
| Date of First Compliant Deposit: | 31 March 2017 |
| Date of Acceptance: | 9 December 2014 |
| Last Modified: | 17 Nov 2024 03:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/68275 |
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