Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome

Davies, Jennifer R. ORCID: https://orcid.org/0000-0001-7415-6129, Humby, Trevor ORCID: https://orcid.org/0000-0002-1840-1799, Dwyer, Dominic M. ORCID: https://orcid.org/0000-0001-8069-5508, Garfield, Alastair S., Furby, Hannah ORCID: https://orcid.org/0000-0002-7279-1812, Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42 (4) , pp. 2105-2113. 10.1111/ejn.12972

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Abstract

Prader–Willi syndrome (PWS) is a neurodevelopmental disorder caused by deletion or inactivation of paternally expressed imprinted genes on human chromosome 15q11-q13, the most recognised feature of which is hyperphagia. This is thought to arise as a consequence of abnormalities in both the physiological drive for food and the rewarding properties of food. Although a number of mouse models for PWS exist, the underlying variables dictating maladaptive feeding remain unknown. Here, feeding behaviour in a mouse model in which the imprinting centre (IC) of the syntenic PWS interval has been deleted (PWSICdel mice) is characterised. It is demonstrated that PWSICdel mice show hyperghrelinaemia and increased consumption of food both following overnight fasting and when made more palatable with sucrose. However, hyperphagia in PWSICdel mice was not accompanied by any changes in reactivity to the hedonic properties of palatable food (sucrose or saccharin), as measured by lick-cluster size. Nevertheless, overall consumption by PWSICdel mice for non-caloric saccharin in the licking test was significantly reduced. Combined with converging findings from a continuous reinforcement schedule, these data indicate that PWSICdel mice show a marked heightened sensitivity to the calorific value of food. Overall, these data indicate that any impact of the rewarding properties of food on the hyperphagia seen in PWSICdel mice is driven primarily by calorie content and is unlikely to involve hedonic processes. This has important implications for understanding the neural systems underlying the feeding phenotype of PWS and the contribution of imprinted genes to abnormal feeding behaviour more generally.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Uncontrolled Keywords:	hyperphagia; lick-cluster analysis; palatability; Prader–Willi syndrome
Publisher:	Wiley-Blackwell
ISSN:	0953-816X
Funders:	BBSRC
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	29 May 2015
Last Modified:	13 May 2023 19:38
URI:	https://orca.cardiff.ac.uk/id/eprint/74544

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