Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein

Reddington, Samuel C., Driezis, Sarunas, Hartley, Andrew M., Watson, Peter Duncan ORCID: https://orcid.org/0000-0003-0250-7852, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Jones, Darran Dafydd ORCID: https://orcid.org/0000-0001-7709-3995 2015. Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein. RSC Advances 5 (95) , pp. 77734-77738. 10.1039/C5RA13552D

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Abstract

The photochemical properties of phenyl azide have been exploited to modulate the function of a red autofluorescent protein, mCherry. Using genetic code reprogramming, phenyl azide chemistry has been introduced at functionally strategic positions in mCherry leading to deactivation, activation or enhancement upon UV irradiation

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Schools > Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	RSC Publishing
ISSN:	2046-2069
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	7 September 2015
Last Modified:	05 May 2023 00:08
URI:	https://orca.cardiff.ac.uk/id/eprint/77897

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