Interferon gamma: A master regulator of atherosclerosis

McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934 and Ramji, Dipak P. ORCID: https://orcid.org/0000-0002-6419-5578 2009. Interferon gamma: A master regulator of atherosclerosis. Cytokine & Growth Factor Reviews 20 (2) , pp. 125-135. 10.1016/j.cytogfr.2008.11.003

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Abstract

Atherosclerosis is a chronic inflammatory disease that is characterized by the development of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its progression is influenced by a number of environmental and genetic risk factors. The cytokine interferon-γ (IFN-γ), a key regulator of immune function, is highly expressed in atherosclerotic lesions and has emerged as a significant factor in atherogenesis. Evidence from both mouse models of atherosclerosis and in vitro cell culture has suggested that the role of IFN-γ is complex since both pro- and anti-atherogenic actions have been affiliated to it. This review will focus on evaluating the contribution of IFN-γ to atherosclerosis and, in particular, how it regulates immune responses to the disease.

Item Type:	Article
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	1359-6101
Last Modified:	17 Oct 2022 10:41
URI:	https://orca.cardiff.ac.uk/id/eprint/8949

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