Emanueli, Costanza, Shearn, Andrew I. U., Laftah, Abas, Fiorentino, Francesca, Reeves, Barnaby C., Beltrami, Cristina, Mumford, Andrew, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Gurney, Mark ORCID: https://orcid.org/0000-0003-1119-6638, Shantikumar, Saran and Angelini, Gianni D. 2016. Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: an example of exosome trafficking out of the human heart with potential for cardiac biomarker discovery. PLoS ONE 11 (4) , e0154274. 10.1371/journal.pone.0154274 |
Preview |
PDF
- Published Version
Available under License Creative Commons Attribution. Download (5MB) | Preview |
Abstract
Exosome nanoparticles carry a composite cargo, including microRNAs (miRs). Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of miRNAs from the heart is largely unexplored. Working on clinical samples from coronary-artery by-pass graft (CABG) surgery, we investigated if: 1) exosomes containing cardiac miRs and hence putatively released by cardiac cells increase in the circulation after surgery; 2) circulating exosomes and exosomal cardiac miRs correlate with cardiac troponin (cTn), the current “gold standard” surrogate biomarker of myocardial damage.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Uncontrolled Keywords: | CABG, coronary artery-by-pass graft surgery; CPB, cardiopulmonary by-pass; cTn, cardiac troponin; cTn-I, cardiac troponin I; EV, extracellular vesicle; MI, myocardial infarct; miR, microRNA |
Publisher: | Public Library of Science |
ISSN: | 1932-6203 |
Funders: | British Heart Foundation |
Date of First Compliant Deposit: | 13 May 2016 |
Date of Acceptance: | 10 April 2016 |
Last Modified: | 05 Jan 2024 06:21 |
URI: | https://orca.cardiff.ac.uk/id/eprint/90769 |
Citation Data
Cited 75 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |