Emanueli, Costanza, Shearn, Andrew I. U., Laftah, Abas, Fiorentino, Francesca, Reeves, Barnaby C., Beltrami, Cristina, Mumford, Andrew, Clayton, Aled ![]() ![]() ![]() |
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Abstract
Exosome nanoparticles carry a composite cargo, including microRNAs (miRs). Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of miRNAs from the heart is largely unexplored. Working on clinical samples from coronary-artery by-pass graft (CABG) surgery, we investigated if: 1) exosomes containing cardiac miRs and hence putatively released by cardiac cells increase in the circulation after surgery; 2) circulating exosomes and exosomal cardiac miRs correlate with cardiac troponin (cTn), the current “gold standard” surrogate biomarker of myocardial damage.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Uncontrolled Keywords: | CABG, coronary artery-by-pass graft surgery; CPB, cardiopulmonary by-pass; cTn, cardiac troponin; cTn-I, cardiac troponin I; EV, extracellular vesicle; MI, myocardial infarct; miR, microRNA |
Publisher: | Public Library of Science |
ISSN: | 1932-6203 |
Funders: | British Heart Foundation |
Date of First Compliant Deposit: | 13 May 2016 |
Date of Acceptance: | 10 April 2016 |
Last Modified: | 05 Jan 2024 06:21 |
URI: | https://orca.cardiff.ac.uk/id/eprint/90769 |
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