Oxenius, A., Price, David  ORCID: https://orcid.org/0000-0001-9416-2737, Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Phillips, R. E.
2000.
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
97
(7)
, pp. 3382-3387.
10.1073/pnas.97.7.3382
|
Abstract
Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection without clear understanding of its immunological effects. Here, we demonstrate that early use of HAART during primary infection preserves HIV-specific CD8+ T cells physically and functionally while HIV-specific T cell help is sustained. We also show that even transient administration of HAART at seroconversion can preserve HIV-specific immunity. In contrast, delayed initiation of HAART is associated with a progressive loss of HIV-specific CD8+ T cells and absent HIV-specific T cell help. These results imply that HIV-specific T help is damaged during primary HIV-1 infection. Early drug treatment, which preserves this immunity, also preserves HIV-specific CD8+ T cells. These results have implications for understanding the early pathogenesis of HIV-1 infection and suggest that acute HIV infection should be treated aggressively and as early as possible.
| Item Type: | Article |
|---|---|
| Status: | Published |
| Schools: | Medicine |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Publisher: | National Academy of Sciences |
| ISSN: | 0027-8424 |
| Date of First Compliant Deposit: | 1 June 2016 |
| Last Modified: | 01 Nov 2022 10:26 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/91447 |
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