Antagonism of cytotoxic T-lymphocyte activation by soluble CD8

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gerth, U. C., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Purbhoo, M. A., Boulter, J. M., Gao, G. F., Bell, J. I., Phillips, R. E. and Jakobsen, B. K. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5 , pp. 399-404. 10.1038/7398

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Abstract

The CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibits activation of cytotoxic lymphocytes by obstructing CD3 zeta-chain phosphorylation. We propose a model for this effect that involves interference of productive receptor multimerization at the T-cell surface. These results provide new insights into the mechanism of T-cell activation and evidence that CD8 function is exquisitely sensitive to disruption, an effect that might be exploited by molecular therapeutics.

Item Type:	Article
Status:	Published
Schools:	Medicine
Publisher:	Nature Publishing Group
ISSN:	1078-8956
Date of First Compliant Deposit:	16 June 2016
Last Modified:	01 Nov 2022 10:31
URI:	https://orca.cardiff.ac.uk/id/eprint/91917

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