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Antagonism of cytotoxic T-lymphocyte activation by soluble CD8

Sewell, Andrew K., Gerth, U. C., Price, David, Purbhoo, M. A., Boulter, J. M., Gao, G. F., Bell, J. I., Phillips, R. E. and Jakobsen, B. K. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5 , pp. 399-404. 10.1038/7398

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The CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibits activation of cytotoxic lymphocytes by obstructing CD3 zeta-chain phosphorylation. We propose a model for this effect that involves interference of productive receptor multimerization at the T-cell surface. These results provide new insights into the mechanism of T-cell activation and evidence that CD8 function is exquisitely sensitive to disruption, an effect that might be exploited by molecular therapeutics.

Item Type: Article
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1078-8956
Date of First Compliant Deposit: 16 June 2016
Last Modified: 04 Jun 2017 09:12

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